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Evaluation of seasonal variation of the main secondary metabolites and anti-inflammatory activity of extracts of Tithonia diversifolia (Hemsl.) A. Gray (Asteraceae)

Grant number: 11/13361-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2011
Effective date (End): May 31, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Fernando Batista da Costa
Grantee:Bruno Leite Sampaio
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


In Brazil several Asteraceae species, both native and exotic, are well known by the population for its medicinal properties. One of these species is Tithonia diversifolia (Hemsl.) A. Gray, known popularly as margaridão, a plant native to Central America and Mexico, acclimatized to Brazil, which has become common in gardens and flowerbeds, and even considered as an invasive plant. It is popularly used as anti-inflammatory, antimalarial, antimicrobial among other uses, and the extracts of this plant have shown many of these activities in different studies, highlighting the anti-inflammatory action of its leaves. Recent studies, including some made in FCFRP-USP, demonstrated that the major classes of substances present in T. diversifolia related to anti-inflammatory action are the sesquiterpene lactones, chlorogenic acids and flavonoids, and some of these components have been identified and isolated. Because the great potential of T.diversifolia as a raw material for the development of a new product (phytomedicine or natural drug), it becomes interesting to study the effects of seasonality on their markers in order to understand how they behave in the plant throughout the year, which is proposed this project. For this study phytochemical analytical methods will be employed (HPLC-DAD, LC-ESI/MS and spectrophotometry UV/vis) and bioassays of pharmacological activity in vitro and in vivo, in order to observe the qualitative and quantitative variation of the main markers from margaridão, correlating the pharmacological activity of its extracts, and thus establish the behavior of the most important secondary metabolites in the pharmacological action. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SAMPAIO, BRUNO LEITE; EDRADA-EBEL, RUANGELIE; DA COSTA, FERNANDO BATISTA. Effect of the environment on the secondary metabolic profile of Tithonia diversifolia: a model for environmental metabolomics of plants. SCIENTIFIC REPORTS, v. 6, . (11/13361-6, 10/51454-3)
CCANA-CCAPATINTA, GARI V.; SAMPAIO, BRUNO L.; DOS SANTOS, JR., FERNANDO M.; BATISTA, JR., JOAO M.; DA COSTA, FERNANDO B.. Absolute configuration assignment of caffeic acid ester derivatives from Tithonia diversifolia by vibrational circular dichroism: the pitfalls of deuteration. TETRAHEDRON-ASYMMETRY, v. 28, n. 12, p. 1823-1828, . (15/07089-2, 11/13361-6, 14/26866-7, 14/25222-9, 14/16850-6, 16/23794-0)
SAMPAIO, BRUNO LEITE; DA COSTA, FERNANDO BATISTA. Influence of abiotic environmental factors on the main constituents of the volatile oils of Tithonia diversifolia. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 28, n. 2, p. 135-144, . (11/13361-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SAMPAIO, Bruno Leite. The influence of environmental factors and seasonal variation of Tithonia diversifolia (Hemls.) A. Gray metabolites and evaluation of the antioxidant, photoprotective and photochemopreventive activities of the extracts in vitro. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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