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Porous osteoconductive material use with and without the GBR technique for healing of cervical bone defects right with implants instalation: a histological, histometric, RFA and micro-tomographic study in dogs

Grant number: 11/09015-5
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): September 01, 2011
Effective date (End): September 30, 2013
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal researcher:Luiz Antonio Salata
Grantee:Antonio Azoubel Antunes
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


A prospective experimental randomized controlled study with 12 male dogs will be done. The first surgical step will be the billateral mandibular pre-molars and molars extractions. In a second moment, five circunferential defects will be performed with a 6-mm-trephine in one site of the mandible. These defects will be grafted with BioOss Block", BioOss Collagen", BioOss" in granules, autogenous bone block and coagulum (control), with a randomized distribution for the five defects. At the same procedure, an implant will be placed in each defect. After eight weeks, other five bone defects will be made in the opposite side, with the same steps described for the first side. After blocks' adaptation, implants will be placed by the mesial margin of the defect, providing tight contact with the block graft (positioned in distal region of the defect) in its cervical region. After the described procedure, membranes BioGide" will be placed in half of the sides by each experimental group, to compare to bone healing of the sides in which they were not placed. Time points of 8 and 16 weeks will be used. After sacrifice, ground sections will be submitted to micro-CT, histological and histometric analysis. Implants stability will be assessed by Resonance Frequency Analysis (RFA) by implant placement and right after sacrifice. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANTUNES, ANTONIO AZOUBEL; GROSSI-OLIVEIRA, GUSTAVO AUGUSTO; MARTINS-NETO, EVANDRO CARNEIRO; GONCALVES DE ALMEIDA, ADRIANA LUISA; SALATA, LUIZ ANTONIO. Treatment of Circumferential Defects with Osseoconductive Xenografts of Different Porosities: A Histological, Histometric, Resonance Frequency Analysis, and Micro-CT Study in Dogs. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, v. 17, n. 1, p. E202-E220, . (11/08911-7, 11/09015-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ANTUNES, Antonio Azoubel. Treatment of cervical bone defects with porous osteoconductive materials in immediate implants: a histological, histometric, micro-CT and RFA study in dogs. 2013. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Odontologia de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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