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Evaluation of the inactivation of breast cancer after photodynamic therapy in vivo

Grant number: 11/05404-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2011
Effective date (End): July 31, 2013
Field of knowledge:Biological Sciences - Biophysics - Radiology and Photobiology
Principal Investigator:Cristina Pacheco Soares
Grantee:Carolina Genúncio da Cunha Menezes Costa
Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil


Cancer is known that the disease has caused more concern in the history of mankind. The three treatments classically adopted for cancer are chemotherapy, radiotherapy and surgery (removal of damaged tissue and its surroundings), which have several disadvantages, such as disfigurement of the patient with damage to their self-esteem, many effects side effects (chemotherapy and radiotherapy), and a prospect of cure is not always effective. Until recently, the cancers were defined according to the tumor cell itself, are now seen as more complex diseases, involving different cell types present in the same microenvironment, immune cells, blood vessels and supporting tissue. Given this new knowledge was the emergence of other possible targets for therapies against these evils. As the interaction between these different cells are better understood, it is possible to develop new forms of treatment. As a result, alternative treatments have been developed, among which include Photodynamic Therapy which has been widely used in Europe, America and some countries in South America however the application of photodynamic therapy, presents some points need to be clarified: the type of photosynthetic (by way of administration, how to prepare, the therapeutic concentration), the radiation source (type of irradiation parameters: wavelength, power, exposure time, pulse duration, frequency pulse), methods for determining the biological response, among others.In this project, aiming to better understand the molecular mechanisms associated with tumor microenvironment propose to evaluate the photodynamic therapy in vivo model. To be used both already approved for PDT photosensitizers and new photosensitizers associated with nanotechnology, with the aim of enhancing the interaction of these cells with tumor cells, comparing the signaling pathways, adhesion and cell death activated as well as their effectiveness in eradicating tumor cells. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE FARIA SOUZA, ROBERTA KELLY; SILVA CARVALHO, ISABEL CHAVES; DA CUNHA MENEZES COSTA, CAROLINA GENUNCIO; DA SILVA, NEWTON SOARES; PACHECO-SOARES, CRISTINA. Alteration of Surface Glycoproteins After Photodynamic Therapy. Photomedicine and Laser Surgery, v. 36, n. 8, p. 452-456, . (16/17984-1, 11/05958-2, 09/15206-8, 11/05404-7)

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