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Evaluation of expression of macrophage migration inhibitory factor (MIF) as prognostic marker in patients with oral squamous cell carcinoma

Grant number: 11/03281-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): October 01, 2011
Effective date (End): March 31, 2013
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Marcos Brasilino de Carvalho
Host Institution: Hospital Heliópolis. Unidade de Gestão Assistencial I. Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas, AP.TEM
Associated scholarship(s):12/08575-0 - In vitro evaluation of the effect of Macrophage Migration Inhibitory Factor (MIF) inhibition in the oral squamous cell carcinoma progression, BE.EP.MS


Protein MIF (Macrophage Migration Inhibitory Factor) is frequently found with high expression in tumor tissues when compared to equivalent normal tissues and has been related between prognostic factors of the various malignancies, including hepatocellular, ovarian, esophageal and also head and neck carcinoma. Additionally, some of its mechanisms of action that have already demonstrated, such as induction of angiogenesis and cell proliferation, allow implying differential expression in tumor progression. This study aims to evaluate the expression of MIF protein as a prognostic marker in squamous cell carcinoma of the oral cavity, checking for differential expression in tumor tissue and margins, serum and saliva of patients with this neoplasia, before and after the treatment, and correlating to the clinical and histopathological aspects and survival.The study will consist of 100 patients with oral squamous cell carcinoma admitted in the Departments of Head and Neck Surgery of the Hospital Heliópolis and Faculdade de Medicina da Fundação ABC. Analyses will be made by immunohistochemistry of tumor tissues and margins, and ELISA of serum and saliva of the selected patients. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, MARIANA BARBOSA; CURIONI, OTAVIO ALBERTO; KANDA, JOSSI LEDO; DE CARVALHO, MARCOS BRASILINO. Serum and salivary macrophage migration inhibitory factor in patients with oral squamous cell carcinoma. Oncology Letters, v. 8, n. 5, p. 2267-2275, . (11/03281-5, 10/20765-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
RIZZO, MARIANA BARBOSA DE SOUZA. Study of Macrophage Migration Inhibitory Factor (MIF) in patients with oral squamous cell carcinoma. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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