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Analysis of structural changes in gray and white matter by magnetic resonance in juvenile systemic lupus erythematosus.

Grant number: 10/13639-1
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2011
Effective date (End): July 31, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Simone Appenzeller
Grantee:Aline Tamires Lapa
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus, AP.JP


Systemic lupus erythematosus (SLE) is a multissistemic disease characterized by periods of activity and remission. Although SLE is more common to be present in adulthood, about 15-20% of patients with SLE occurs before 16 years. There is a significant majority of females (4: 1) also in pediatric patients. Children and adolescents generally have a severe form of disease presentation, and also the development of disease and injury more quickly than adults with SLE and have a higher burden of disease throughout their lives. The central nervous system involvement is frequent in patients with juvenile SLE and with high morbidity and mortality, but often is observed a dissociation between clinical and neuroimaging findings and clinical assessment with neuropsychological tests can be effective as a diagnostic tool. In magnetic resonance imaging (MRI) in patients with juvenile SLE can be observed atrophy, white matter lesions and other structural changes. But until this moment there are few studies evaluating the prevalence of structural changes in juvenile SLE and factors associated with its occurrence. This study aims to determine the prevalence of neuropsychiatric manifestations in SLE youth and to determine the prevalence of structural MRI and its associated factors. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARBOSA, RENATA; POSTAL, MARIANA; COSTALLAT, LILIAN TEREZA LAVRAS; CENDES, FERNANDO; APPENZELLER, SIMONE. Cognitive Impairment in Systemic Lupus Erythematosus: Prevalence and Clinical Importance. CURRENT RHEUMATOLOGY REVIEWS, v. 8, n. 1, p. 10-pg., . (10/13639-1, 09/11076-2)
AMARAL, TIAGO NARDI; MARQUES NETO, JOAO FRANCISCO; LAPA, ALINE TAMIRES; PERES, FERNANDO AUGUSTO; GUIRAU, CAIO RODRIGUES; APPENZELLER, SIMONE. Neurologic Involvement in Scleroderma en Coup de Sabre. AUTOIMMUNE DISEASES, v. 2012, p. 7-pg., . (08/02917-0, 10/13639-1, 09/06049-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LAPA, Aline Tamires. Analysis of structural changes in gray and white matter by magnetic resonance in juvenile systemic lupus erythematosus. 2013. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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