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Evaluation of the protease activated receptor 2(PAR-2) expression in chronic periodontitis patients, before and after non-surgical periodontal treatment

Grant number: 10/20477-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2011
Effective date (End): June 30, 2014
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Marinella Holzhausen Caldeira
Grantee:Vanessa Tubero Euzebio Alves
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):12/22439-1 - Role of Protease-Activated receptor 2 (PAR2) during Porphyromonas gingivalis infection on the regulation of p38-MAPK signaling in periodontal cells, BE.EP.DR


The association of protease activated receptor 2 (PAR-2) with periodontitis, an oral chronic inflammation that leads to bone loss and consequently to tooth loss, was first suggested by in vitro studies which have demonstrated that osteoblasts, epithelial cells and human gingival fibroblasts express PAR-2. In addition, it was observed that local administration of a PAR-2 selective agonist (SLIGRL) causes gingival granulocyte infiltration and periodontitis in rats. Furthermore, PAR-2 knockout mice (PAR-2-/-) showed less inflammation due to Porphyromonas gingivalis (Pg) infection. In a recent study by our group, we have shown that in chronic periodontitis patients, an increased genetic expression of PAR-2 is associated to the presence of increased levels of pro-inflammatory mediators, total proteolytic activity, proteinase-3, and increased Pg prevalence, from which gingipain is derived. However, these results did not show whether this genetic expression is found increased due to the presence of periodontal disease or due to a constitutive feature that favors the commencement of periodontal disease. Therefore, in this present study, crevicular cells will be evaluated regarding the correlation between genetic and protein expression of PAR-2 (Real Time-PCR, Western blot) and the periodontal clinical parameters in human chronic periodontitis, before and after conventional periodontal treatment.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ABREU, I. S.; EUZEBIO ALVES, V. T.; BENEDETE, A. P. S.; BUENO DA SILVA, H. A.; FRANCA, B. N.; SARAIVA, L.; LIMA, L. A.; CARVALHO, M. H.; HOLZHAUSEN, M.. Gingival crevicular fluid levels of protease-activated receptors type 1 and type 2 in diabetic patients with periodontitis. JOURNAL OF PERIODONTAL RESEARCH, v. 51, n. 5, p. 577-585, . (09/16373-5, 10/20477-8, 14/06387-7, 10/16605-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ALVES, Vanessa Tubero Euzebio. Evaluation of the protease activated receptor 2 (PAR2) expression in chronic periodontitis patients, before and after non-surgical periodontal treatment. 2014. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Odontologia (FO/SDO) São Paulo.

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