| Grant number: | 11/00432-2 |
| Support type: | Scholarships in Brazil - Scientific Initiation |
| Effective date (Start): | August 01, 2011 |
| Effective date (End): | December 31, 2012 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Organic Chemistry |
| Principal researcher: | José Agustín Pablo Quincoces Suárez |
| Grantee: | José Matheus Freitas Costa |
| Home Institution: | Coordenadoria de Pesquisa. Universidade Bandeirantes (UNIBAN). São Paulo , SP, Brazil |
Abstract We planed the synthesis of 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB1 and derivatives. The analgesic properties of this molecule will be determined (analgesic assay in rats). Therefore, we planed the use of this molecule as pH indicator.The synthesis of push-pull butadienes starting from hydroxyacetophenones shall be realized under Vilsmeier-Haack and Knoevenagel reaction conditions. All the compounds will be purified and their structure shall be characterized by spectroscopic methods and organic elemental quantitative analysis. | |
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