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Role of Nox2 derived products in the pathogenesis of sepsis

Grant number: 11/03293-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2011
Effective date (End): November 30, 2014
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Fernando de Queiroz Cunha
Grantee:Silvia Cellone Trevelin
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:07/51247-5 - Mediators involved in the genesis of pain and the migration of leukocytes and in sepsis, AP.TEM
Associated scholarship(s):12/24677-7 - The role of Nox2 in endothelial dysfunction and failure of neutrophil migaration to focus of infection in sepsis, BE.EP.DR


Neutrophils are the first defense line of the organism to bacterial infections, and their recruitment and generation of reactive oxygen and nitrogen species (ROS and RNS) are essential to combat the microorganisms. In spite of the important microbicidal role, this substances may oxide cellular components and interfere with their function. The ability of nitric oxide and peroxinitrite to reduce neutrophil migration to the focus of inflammation/infection is well recognized, but the action of superoxide and others ROS in neutrophil recruitment differs among several studies. Since sepsis is defined as a systemic inflammatory response to infection and characterized by significant oxidative stress, we will use the cecal ligation and puncture (CLP) as sepsis model in mice gp91phox knockout and wild type to verify whether Nox2 derived work in the modulation of neutrophil migration to the primary focus of infection. Also we propose to analise the possible mechanisms envolved on this process. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TREVELIN, SILVIA CELLONE; DOS SANTOS, CELIO XAVIER; FERREIRA, RAPHAEL GOMES; LIMA, LARISSA DE SA; SILVA, RANGEL LEAL; SCAVONE, CRISTOFORO; CURI, RUI; CARLOS ALVES-FILHO, JOSE; CUNHA, THIAGO MATTAR; ROXO-JUNIOR, PERSIO; et al. Apocynin and Nox2 regulate NF-kappa B by modifying thioredoxin-1 redox-state. SCIENTIFIC REPORTS, v. 6, . (12/24677-7, 09/54764-6, 13/08216-2, 13/03520-5, 11/19670-0, 11/03293-3, 13/07937-8)
HERNANDES, MARINA S.; D'AVILA, JOANA C.; TREVELIN, SILVIA C.; REIS, PATRICIA A.; KINJO, ERIKA R.; LOPES, LUCIA R.; CASTRO-FARIA-NETO, HUGO C.; CUNHA, FERNANDO Q.; BRITTO, LUIZ R. G.; BOZZA, FERNANDO A.. The role of Nox2-derived ROS in the development of cognitive impairment after sepsis. JOURNAL OF NEUROINFLAMMATION, v. 11, . (11/03293-3)
TREVELIN, SILVIA C.; CARLOS, DANIELA; BERETTA, MATTEO; DA SILVA, JOAO S.; CUNHA, FERNANDO Q.. Diabetes Mellitus and Sepsis: A Challenging Association. Shock, v. 47, n. 3, p. 276-287, . (13/08216-2, 11/03293-3, 11/19670-0, 09/54764-6)
SOUTO, FABRICIO O.; CASTANHEIRA, FERNANDA V. S.; TREVELIN, SILVIA C.; LIMA, BRAULIO H. F.; MARTELOSSI CEBINELLI, GUILHERME CESAR; TURATO, WALTER M.; AUXILIADORA-MARTINS, MARIA; BASILE-FILHO, ANIBAL; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO Q.. Liver X Receptor Activation Impairs Neutrophil Functions and Aggravates Sepsis. Journal of Infectious Diseases, v. 221, n. 9, p. 1542-1553, . (13/08216-2, 11/03293-3, 09/07651-1)

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