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Body composition and bone mineral density in users of depot medroxyprogesterone acetate compared to CIU Tcu380A Intrauterine Device

Grant number: 11/01554-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2011
Effective date (End): November 30, 2014
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Luis Guillermo Bahamondes
Grantee:Waleska Oliveira Modesto
Host Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):12/05828-4 - Assessment of body composition and bone mineral density in users of depot medroxyprogesterone acetate, BE.EP.DR


The contraceptive methods (MACs) are used hormonal largely due to the high efficiency. In recent years numerous studies have been published about contraceptives, bone loss and fracture risk, they often are administered for prolonged periods and in a stage of life that has not yet reached peak bone mass formation, as in use in adolescent women.Among the injectable hormonal MACs, the depot medroxyprogesterone acetate (DMPA) contraception is the most studied in relation to effects on mienral density (BMD). Concern about the effect of DMPA on BMD began soon after the approval of the use of this medication in the U.S. in 1992, and is basically the state of hypoestrogenism caused by the method.Studies have shown an increase in body weight, but there is almost no evidence on the body composition of AMDP system users. The assessment of body composition is of great importance in checking the nutritional status, prediction of bone mass and development of appropriate conduct, since the excess fat is associated with several chronic diseases.A diet rich in calcium and vitamin D associated with physical activity impact, are proven methods to reduce the loss of BMD. The use of MACs hormone remains controversial, there is no consensus on the specific use of DMPA and bone mass. Given this aspect is relevant to verify the possible effects of habits such as physical activity, sun exposure and calcium intake, as well as the presence of vitamin D deficiency in women using DMPA compared to women without the use of method hormonal.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MODESTO, WALESKA; DALAVA, NATALIA; MONTEIRO, ILZA; BAHAMONDES, LUIS. Body composition and bone mineral density in users of the etonogestrel-releasing contraceptive implant. ARCHIVES OF GYNECOLOGY AND OBSTETRICS, v. 292, n. 6, p. 1387-1391, . (11/01554-4, 12/12432-0)
MODESTO, WALESKA; VALERIA BAHAMONDES, M.; DOS SANTOS, PRISCILA SILVA; FERNANDES, ARLETE; DAL'AVA, NATALIA; BAHAMONDES, LUIS. Exploratory study of the effect of lifestyle counselling on bone mineral density and body composition in users of the contraceptive depot-medroxyprogesterone acetate. EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE, v. 19, n. 4, p. 244-249, . (11/01554-4, 09/53293-0)
MODESTO, WALESKA; SILVA DOS SANTOS, PRISCILA DE NAZARE; CORREIA, VINICIUS MACHADO; BORGES, LUIZA; BAHAMONDES, LUIS. Weight variation in users of depot-medroxyprogesterone acetate, the levonorgestrel-releasing intrauterine system and a copper intrauterine device for up to ten years of use. EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE, v. 20, n. 1, p. 57-63, . (11/01554-4, 13/03590-3)
MODESTO, WALESKA; BAHAMONDES, M. VALERIA; BAHAMONDES, LUIS. Prevalence of Low Bone Mass and Osteoporosis in Long-Term Users of the Injectable Contraceptive Depot Medroxyprogesterone Acetate. JOURNAL OF WOMENS HEALTH, v. 24, n. 8, p. 636-640, . (11/01554-4, 13/03590-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MODESTO, Waleska Oliveira. Assessment of clinical, bone mineral density, body composition and weight among users of progestin-only contraceptives. 2014. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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