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The study of neurogenesis and synaptic plasticity in rats submitted to the maternal separation and enriched environment

Grant number: 10/18446-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2011
Effective date (End): October 31, 2014
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Jorge Eduardo Moreira
Grantee:Suelen Merlo
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The maternal separation, considered for many researchs as a model of depression and postnatal stress, promotes several behavioral and brain changes. Animals submitted to the maternal separation have, during adulthood, incresead responses of the HPA axis to stress stimuli, reduction of the hippocampal neurogenesis and reduction of the desinty of dentritic spines in several brain structures. The enriched environment increases the neurogenesis in the dentate gyrus of the hippocampus, with beneficial effects in behavioral disorders. The present project will be conducted to test the hypothesis that the enriched environment can attenuate some cerebral changes promoted by maternal separation. Pregnant rats will be accompanied daily and the pups will be isolated from their mothers 3 h per day from the 1º to 14º postnatal day. After weaning (day 21), the pups will be submitted to the enriched environment, one environment where the animals will have more opportunities to social interaction, physical exercise and more opportunities for learning. The hippocampus of adolescent and adult animals (submitted or not to the maternal separation and to the enriched environment) will be removed for the analysis of the neurogenesis and apoptosis in the hippocampal neuronal cells. In addition, the number and morphology of dendritic spines as well as the expression of protein and mRNA for glucocorticoid receptors will be analyzed in the dorsal and ventral hippocampus of the animals from all experimental groups.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MERLO, Suelen. Neurogenesis and synaptic plasticity in the hippocampus of rats submitted to maternal separation and environmental enrichment. 2014. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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