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Solid lipid nanoparticles production by low-energy method: process optimization, evaluation of bioactive absorption and in vitro digestibility

Grant number: 10/20523-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2011
Effective date (End): February 28, 2015
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Engineering
Principal Investigator:Samantha Cristina de Pinho
Grantee:Graziela Veiga de Lara Gomes
Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
Associated scholarship(s):12/18495-3 - In vitro dynamic digestibility of solid lipid nanoparticles encapsulating beta-carotene, BE.EP.DR


The use for encapsulation of lipid formulations have been investigated for increasing the bioavailability of hydrophobic bioactive a v and lipid materials that may enhance absorption of these compounds in the intestinal membrane. Different types of particles may be described for the production of lipid encapsulation systems, among them the solid lipid particles consisting of lipid particles coated with an emulsifier and dispersed in an aqueous medium where lipid phase is partly or fully solidified. Such structures are known as SLN - solid lipid nanoparticles, or solid lipid particles. Such particles have important advantages, such as high physical and chemical stability, protection against degradation of susceptible active, controlled release and excellent tolerability and can be produced by methods involving high amount of energy in the system or low energy. In the first case, the smaller the desired size, more power and / or surfactant are required, which makes the often extremely expensive for industrial applications. Moreover, low energy methods are interesting for scheduling, as are theoretically relatively simple and has low energy consumption. Among the low-energy methods, it is the PIT method (English, phase inversion temperature) based on the change in solubility of nonionic surfactants polyethoxylated with temperature. The main objective of the proposed study is the production of solid lipid nanoparticles encapsulating beta-carotene through the PIT method, and evaluation of absorption and digestibility of cytotoxicity produced systems. If approved, this project will have a part held on the premises of ZEA / FZEA / USP (Macromolecules functionality Laboratory) in the same department. For the realization of the other party will be requested to CAPES or FAPESP itself an internship abroad or Doctorate-sandwich that will be performed in the Department of Biological Engineering, University of Minho (Campus of Gualtar), Braga, Portugal and the Institute of Biotechnology and Bioengineering, Centre of Genomics and Biotechnology at the University of Tras-os-Montes and Alto Douro (IBB / CGB-UTAD), Guimarães, Portugal (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES, GRAZIELA V. L.; SOLA, MIRELLA R.; MAROSTEGAN, LUIS F. P.; JANGE, CAMILA G.; CAZADO, CAMILA P. S.; PINHEIRO, ANA C.; VICENTE, ANTONIO A.; PINHO, SAMANTHA C.. Physico-chemical stability and in vitro digestibility of beta-carotene-loaded lipid nanoparticles of cupuacu butter (Theobroma grandiflorum) produced by the phase inversion temperature (PIT) method. Journal of Food Engineering, v. 192, p. 93-102, . (11/01260-0, 12/18495-3, 10/20523-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GOMES, Graziela Veiga de Lara. Production by phase inversion temperature method, study of physicochemical stability, in vitro digestibility and cytotoxicity of beta-carotene load solid lipid nanoparticle. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Zootecnica e Engenharia de Alimentos (FZE/BT) Pirassununga.

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