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Involvement of the glutamatergic neurotransmission in the inferior colliculus on the catalepsy induced by intraestriatal haloperidol microinjection

Grant number: 10/14446-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2011
Effective date (End): February 28, 2013
Field of knowledge:Humanities - Psychology - Physiological Psychology
Principal Investigator:Liana Melo-Thomas
Grantee:Priscila Medeiros de Freitas
Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil


The inferior colliculus (IC) is primarily involved in auditory information processing but also integrates sensory information of aversive nature. Aberrant processing of auditory information may be at the root of auditory delusions commonly seen in schizophrenic patients. It has been shown that that the activation of the neural substrates of aversion of the IC by excitatory amino acids (EAA) causes freezing, escape behavior and tonic immobility and that the electrical stimulation of the IC increases the extracellular levels of dopamine in the frontal cortex. However, the nature of this tonic immobility and how it relates with catalepsy induced by dopamine receptor blockers such as the haloperidol are unclear. This study will examine the influence of EAA-mediated mechanisms of the IC on the catalepsy induced by intrastriatal microinjection of haloperidol (2.5¼g/0.5µl). To this end, haloperidol-induced catalepsy will be challenged with prior intracollicular microinjections of MK-801(2.5 or 5µg/0.5µl), AP7 (10 or 20 nmol/0.5µl) or NMDA (20 or 30 nmol/0.5µl). Immediately after the time of catalepsy will be measured.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE FREITAS, RENATO LEONARDO; SALGADO-ROHNER, CARLOS JOSE; BIAGIONI, AUDREY FRANCISCO; MEDEIROS, PRISCILA; CECILIO HALLAK, JAIME EDUARDO; CRIPPA, JOSE ALEXANDRE S.; COIMBRA, NORBERTO CYSNE. NMDA and AMPA/Kainate Glutamatergic Receptors in the Prelimbic Medial Prefrontal Cortex Modulate the Elaborated Defensive Behavior and Innate Fear-Induced Antinociception Elicited by GABA(A) Receptor Blockade in the Medial Hypothalamus. CEREBRAL CORTEX, v. 24, n. 6, p. 1518-1528, . (08/08955-1, 10/15140-4, 10/14446-2, 09/17258-5)
MEDEIROS, P.; VIANA, M. B.; BARBOSA-SILVA, R. C.; TONELLI, L. C.; MELO-THOMAS, L.. Glutamatergic neurotransmission in the inferior colliculus influences intrastriatal haloperidol-induced catalepsy. Behavioural Brain Research, v. 268, p. 8-13, . (09/01437-8, 11/01409-4, 10/14446-2)
ZANGRANDO, JULIA; CARVALHEIRA, RENATA; LABBATE, GIOVANNA; MEDEIROS, PRISCILA; LONGO, BEATRIZ MONTEIRO; MELO-THOMAS, LIANA; BARBOSA SILVA, REGINA CLAUDIA. Atypical antipsychotic olanzapine reversed deficit on prepulse inhibition of the acoustic startle reflex produced by microinjection of dizocilpine (MK-801) into the inferior colliculus in rats. Behavioural Brain Research, v. 257, p. 77-82, . (12/01062-7, 11/01409-4, 12/05021-3, 10/14446-2, 12/06275-9)

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