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Correlation between human papillomavirus (HPV) and Epstein-Barr virus (EBV) in patients with oropharynx squamous cell carcinoma. Survival analysis.

Grant number: 10/18527-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2011
Effective date (End): December 31, 2011
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Glauco Issamu Miyahara
Grantee:Gláucia Resende Soares
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The human papillomavirus (HPV) is considered the mainly etiologic factor of cervical cancer and his role in oropharynx squamous cell carcinoma is much studied. Epstein-Barr virus (EBV) affects 90% of the world population, being highly associated with some types of cancer and immunosuppression, however its direct relationship to oral carcinomas has not been fully proven. The aim of this study is to measure the presence of HPV and EBV in paraffin embedded samples obtained by biopsy of patients with oropharynx squamous cell carcinoma, correlate the presence of these viruses among themselves and each one in relation to survival. Forty patients with oropharynx squamous cell carcinoma will be used. Will be extracted DNA samples and its amplification by polymerase chain reaction (PCR) for detection of human betaglobin gene and for the viruses. Correlation between the HPV and EBV will be studied by the application of statistical tests (chi-square or Fisher's exact test) with significance level of 5%. Survival curve in 5 years will be evaluated with Kaplan & Meier's method and Log-Rank test.

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