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Synthesis and evaluation of cytotoxic activity of gama-dihydropyrones: goniothalamin and abyssinone II analogues

Grant number: 10/16990-1
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): March 01, 2011
Effective date (End): May 31, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Ronaldo Aloise Pilli
Grantee:Júlio Cezar Pastre
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:09/51602-5 - Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action, AP.TEM
Associated scholarship(s):12/05909-4 - Preparation of goniothalamin under flow reaction conditions, BE.EP.PD
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARCELOS, ROSIMEIRE COURA; PASTRE, JULIO CEZAR; CAIXETA, VANESSA; VENDRAMINI-COSTA, DEBORA BARBOSA; DE CARVALHO, JOAO ERNESTO; PILLI, RONALDO ALOISE. Synthesis of methoxylated goniothalamin, aza-goniothalamin and gamma-pyrones and their in vitro evaluation against human cancer cells. Bioorganic & Medicinal Chemistry, v. 20, n. 11, p. 3635-3651, . (09/51602-5, 10/16990-1)
BARCELOS, ROSIMEIRE COURA; PASTRE, JULIO CEZAR; VENDRAMINI-COSTA, DEBORA BARBOSA; CAIXETA, VANESSA; LONGATO, GIOVANNA BARBARINI; MONTEIRO, PAULA ARAUJO; DE CARVALHO, JOAO ERNESTO; PILLI, RONALDO ALOISE. Design and Synthesis of N-Acylated Aza-Goniothalamin Derivatives and Evaluation of Their in vitro and in vivo Antitumor Activity. CHEMMEDCHEM, v. 9, n. 12, p. 2725-2743, . (12/18281-3, 09/51602-5, 10/16990-1)
BARCELOS, ROSIMEIRE COURA; PELIZZARO-ROCHA, KARIN JULIANE; PASTRE, JULIO CEZAR; DIAS, MARINA PEREIRA; FERREIRA-HALDER, CARMEN VERISSIMA; ALOISE PILLI, RONA IDO. A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 87, p. 745-758, . (10/15496-3, 09/51602-5, 10/16990-1, 12/24385-6)

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