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Transformation of lignan (-)-grandisin by microorganisms and hepatic microsomes: an alternative to new drugs metabolism studies.

Grant number: 10/12765-3
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2010
Effective date (End): June 30, 2011
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Mônica Tallarico Pupo
Grantee:Gisele Baraldi Messiano
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:09/51812-0 - Development of a platform for the study of in vitro and in vivo metabolism of natural products, a need for pre-clinical testing system, AP.BTA.TEM


Biotransformation is the essential step to obtain information about the new drugs metabolism, and microorganism, in many cases, can be used in vitro assays. It is necessary the correct selection of the microorganism and the culture conditions, because the process optimization is essential to good results. Thus, we propose the biotransformation of a lignan with a potent trypanocidal activity, by different microorganisms and rat hepatic microsomes.

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