The research plan aims the design and total syntheses of novel analogues of fostriecin, a natural compound with antitumoral activity and phosphatase inhibition properties. The target compounds will be hybrid structures of fostriecin and p-coumaric and caffeic acids in order to evaluate the contribution of the hydroxystirenic moiety to the cytotoxic and phosphatase inhibtion properties of these compounds. In addition to the in vitro evaluation of the cytotoxic properties of these compounds, in silico studies will be carried out using molecular docking in order to define the most promising compounds for the in vitro evaluation of phosphatase inhibition properties. The research proposal is expected to contribute with fostriecin analogues with better chemical stability and to a better understanding of the structural requirements for the expression of the pharmacological properties of the fostriecin family of compounds which may contribute for their therapeutical action.
News published in Agência FAPESP Newsletter about the scholarship: