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Bone healing around dental implants placed in surgical alveolus prepared using drills, piezosurgery and Er,Cr:YSGG laser - Radiographic, biomechanical, histomorphometric and immunohistochemical study in rats.

Grant number: 10/07712-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2010
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal researcher:Elcio Marcantonio Junior
Grantee:Jônatas Caldeira Esteves
Home Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):12/16764-7 - Exression of cytokines and gorwth factors in the bone repair of defects produced by burs and surgical ultrassound, BE.EP.DR


The aims of this paper is to analyze the process of bone healing and osseointegration of implants placed in beds prepared by conventional burs (C), piezoelectric device (P) and Er, Cr: YSGG laser (L). For this purpose, two separate studies will be conducted. In Study 1, 144 mice will be divided into three groups (C, P, L) with 48 animals each. The animals will be anesthetized and both tibia will be surgically exposed will to create a surgical alveolus of 2 mm in diameter at the metaphysis of both tibiae. Then a machined implant will be inserted in each socket created. Eight animals in each group will be sacrificed at zero, 3, 7, 15, 30 and 60 days postoperatively. After sacrifice, the implant of the right tibia will be used for analysis of subtraction radiography and, subsequently, analysis of removal torque. The left tibia implant will be used to laboratory processing non-decalcified histological sections for histometric analysis. In Study 2, 144 rats will be divided into three groups with 48 animals each (C, P and L) in the same way as in the previous study. A 2mm in diameter defect will be done in each right tibia metaphysis according to each group. After sacrifice, for the same periods of study 1, the specimens will be reduced and subjected to laboratory processing for histological, histometric and immunohistochemistry analysis. The obtained values will be submitted to statistical analysis (p=0,05) The results obtained in both studies will be used comparatively to understand the process of bone formation around the implants.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ESTEVES, JONATAS CALDEIRA; DE SOUZA FALONI, ANA PAULA; MACEDO, PAULA DELELLO; NAKATA, PATRICIA BORGES; CHIERICI MARCANTONIO, ROSEMARY ADRIANA; INTINI, GIUSEPPE; MARCANTONIO, JR., ELCIO. Effects on Bone Repair of Osteotomy With Drills or With Erbium, Chromium: Yttrium-Scandium-Gallium-Garnet Laser: Histomorphometric and Immunohistochemical Study. Journal of Periodontology, v. 87, n. 4, p. 452-460, . (10/16645-2, 10/07712-8)
ESTEVES, JONATAS CALDEIRA; MARCANTONIO, JR., ELCIO; DE SOUZA FALONI, ANA PAULA; GODOY ROCHA, FERNANDA REGINA; MARCANTONIO, ROSEMARY ADRIANA; WILK, KATARZYNA; INTINI, GIUSEPPE. Dynamics of bone healing after osteotomy with piezosurgery or conventional drilling - histomorphometrical, immunohistochemical, and molecular analysis. JOURNAL OF TRANSLATIONAL MEDICINE, v. 11, . (10/16645-2, 12/16764-7, 10/07712-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)

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