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Blood groups polymorphisms in patients with multiple transfusions and patients with autoimmune hemolytic anemia: implications in immune response and transfusion practice.

Grant number: 10/06916-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2010
Effective date (End): July 31, 2013
Field of knowledge:Biological Sciences - Immunology - Immunogenetics
Principal Investigator:Lilian Maria de Castilho
Grantee:Gláucia Andréia Soares Guelsin
Host Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The knowledge of blood group antigens is essential to transfusional practice, because antibodies against those antigens can be a major problem in the clinic, mainly in the cases of patients with hemoglobinopathies or others diseases that require blood transfusions. Blood group genotyping can contribute significantly in the quality of the phenotyped transfused blood, especially in multi-transfused patients. Based on this one of our goal is establish a specific genotyping protocol for patients with myelodysplasia and autoimmune hemolytic anemia (AIHA), using real time PCR and microarray techniques, with the objective of avoid hemolytic transfusion reactions and red blood cell (RBC) alloimmunization after transfusion. However, the alloimmunization do not occur in all incompatibility cases for all polytransfused patients groups and according with the literature, some polytransfused patients groups are more responders to allogenic transfusions than others. A possible explication to selective answer for these antigens is the genetic predisposition to alloimmunization that can be related with HLA phenotype. So, another goal is to analyze a possible association between HLA-DRB1 and the immune response to a variety of blood group antigens. Based on the difficult of obtain compatible blood to autoimmune hemolytic anemia patients and that the RBC antigen expression can be decreased in the red cell surface of AIHA patients in the active phase of the disease, we have also the objective to determine the blood group antigen expression in those patients to associate the auto-antibody identity to the antigen that was lost or had decreased expression in the red cell membrane.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUELSIN, GLAUCIA A. S.; RODRIGUES, CAMILA; VISENTAINER, JEANE E. L.; CAMPOS, PAULA DE MELO; TRAINA, FABIOLA; GILLI, SIMONE C. O.; SAAD, SARA T. O.; CASTILHO, LILIAN. Molecular matching for Rh and K reduces red blood cell alloimmunisation in patients with myelodysplastic syndrome. BLOOD TRANSFUSION, v. 13, n. 1, p. 53-58, . (10/06916-9, 12/04651-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GUELSIN, Gláucia Andréia Soares. Blood group and HLA polymorphisms in patients with myelodysplastic syndrome and their implications in erythrocyte alloimmunization. 2014. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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