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Use of "one pot" multicomponent reactions for the synthesis of new compounds of biological interest

Grant number: 10/04875-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2010
Effective date (End): July 31, 2012
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Paulo Marcos Donate
Grantee:Eduardo Hilário Bontempo Silva
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The initial goal of this research project is the identification of new compounds with properties of anti-apoptotic and anti-inflammatory for the treatment of neurodegenerative diseases. Next, it is planned to be carried out the synthesis and the biological evaluation of potential inhibitors.As a starting point, we will to synthesize some analogues of peptides Ac-YVAD, and Ac-DEVD, that are inhibitors of caspase-1 and caspase-3 respectively, using "one pot" multicomponent reactions.The first biological tests to be performed with the analogues synthesized should indicate new structures or changes in the skeletons of the molecules that can have higher inhibitory activity.This project relies on the close collaboration of researchers from the Faculty of Pharmaceutical Sciences of Ribeirao Preto of University of Sao Paulo, which will be responsible for conducting the biological assays with the synthesized compounds.

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