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Relationship between stress associated with academic activities and volatile sulfur compounds production: involvement of beta-defensin

Grant number: 10/01642-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2010
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Fernanda Klein Marcondes
Grantee:Patricia Oliveira de Lima
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


Halitosis is the emanation of malodours from the oral cavity and can have major detrimental social implications for the sufferer and significant impact on normal social interactions. In most cases, their origin is related to the action of Gram-negative anaerobic bacteria in the oral cavity, which degrade sulfur-containing amino acids, producing volatile sulfur compounds (VSC). However, many patients complain about bad breath and do not show obvious clinical cause. So, emotional changes, such as stress and anxiety, have been related to its production, although there are few studies about this relationship. It is known that stress decreases immunity through the suppression of cellular and humoral responses, responsible for the defense mechanisms of the body. Moreover, beta-defensins, peptides that have antimicrobial and immunoregulatory activity, have great importance in health and diseases related to the oral cavity. Thus, our aim is to investigate the relationship between emotional changes, associated with academic activities, expression of beta-defensin 2 in oral cavity and volatile sulfur compounds production.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE LIMA, PATRICIA OLIVEIRA; NANI, BRUNO DIAS; ROLIM, GUSTAVO SATOLLO; GROPPO, FRANCISCO CARLOS; FRANZ-MONTAN, MICHELLE; ALVES DE MORAES, ANTONIO BENTO; COGO-MULLER, KARINA; MARCONDES, FERNANDA KLEIN. Effects of academic stress on the levels of oral volatile sulfur compounds, halitosis-related bacteria and stress biomarkers of healthy female undergraduate students. JOURNAL OF BREATH RESEARCH, v. 14, n. 3, . (08/01641-1, 14/11481-2, 11/50419-2, 10/01642-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LIMA, Patricia Oliveira de. Influence of stress and gender on the volatile sulfur compounds and salivary biomarkers production. 2014. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.

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