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Molecular aspects of the effect of transforming growth factor - beta 1(TGF-b1)and glucocorticoids in vitro signaling pathways biomineralization

Grant number: 10/00352-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2010
Effective date (End): July 31, 2013
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal researcher:Victor Elias Arana-Chavez
Grantee:Tatiani Ayako Goto Donato
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


This project proposes to investigate the molecular effects of TGF ² and Dex, blocking its receptors and studying some elements of their signaling pathways and the role of the ability of differentiation of osteogenic cells at different stages corresponding to biomineralization, making studies chemistry - alkaline phosphatase activity, timing of mineral nodules by the method of immunohistochemistry, the expression of non-collagen proteins such as OPN, BSP, OC and ON, involved in this process by immunofluorescence confocal microscopy, as well as quantification Western-blot and RT-PCR.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
DONATO, Tatiani Ayako Goto. Molecular aspects of the effect of transforming growth factor-beta 1 (TGF-β1) in the signaling pathways in vitro biomineralization.. 2014. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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