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Morita-Baylis-Hillma in synthesis: structural diversity and biological evaluation of spirocyclohexadienones

Grant number: 09/18390-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2010
Effective date (End): February 28, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Fernando Antonio Santos Coelho
Grantee:Lucimara Júlio Martins
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:09/51602-5 - Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action, AP.TEM

Abstract

Recently we have developed a new methodology to prepare spirocyclohexadienones from Morita-Baylis-Hillman adducts. This method is based on the use of a Heck reaction associated to a phenolic oxidation mediated by hypervalent iodine reagents. This phD roject has as purpose increasing the scope of this method and prepare new spirocycloexadienones with different structural diversity. This structural diversity will allow us to evaluate the bactericide and anti-tumoral activities of these compounds. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINS, LUCIMARA J.; FERREIRA, BRUNO R. V.; ALMEIDA, WANDA P.; LANCELLOTTI, MARCELO; COELHO, FERNANDO. An easy access to halogenated and non-halogenated spiro-hexadienones. Tetrahedron Letters, v. 55, n. 38, p. 5264-5267, . (09/51602-5, 09/18390-4, 11/20033-5)
MARTINS, LUCIMARA JULIO; SIMONI, DEBORAH DE ALENCAR; APARICIO, RICARDO; COELHO, FERNANDO. Crystal structure of methyl 2-(2H-1,3-benzodioxol-5-yl)-7,9-dibromo-8-oxo1-oxaspiro[4.5]deca-2,6,9-triene-3-carboxylate. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, v. 70, p. 9-pg., . (09/51602-5, 09/18390-4)
MARTINS, LUCIMARA JULIO; SIMONI, DEBORAH DE ALENCAR; APARICIO, RICARDO; COELHO, FERNANDO. Crystal structure of 3-methoxycarbonyl-2-(4-methoxypheny1)-8-oxo-1-azaspiro-[4.5]deca-1,6,9-trien-1-ium-1-olate. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, v. 70, p. 9-pg., . (09/51602-5, 09/18390-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARTINS, Lucimara Júlio. Morita-Baylis-Hillman em síntese: diversidade estrutural e avaliação biológica de espiro-hexadienonas. 2014. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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