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Prostate evaluation of the male and female senile gerbils exposed to ethinylestradiol during pre natal and pubertal period

Grant number: 09/16790-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2010
Effective date (End): February 28, 2014
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Sebastião Roberto Taboga
Grantee:Ana Paula da Silva Perez
Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil


The developing prostate is under hormonal regulation, is mediated primarily by androgens ordering the growth and differentiation of this gland. However, developing prostate is sensitive to other proteins and steroid hormones, including estrogen. The formation of the embryological prostate female human and rodent occurs in an environment free of steroid hormones, but the secretion of hormones by the ovaries and the adrenal gland promotes the differentiation and secretory activity of the gland in adult life. However, known that during pregnancy, male fetuses are exposed in uterus to maternal estrogen levels are capable of eliciting pathological aberrant proliferation in adult animal. In this regard, little is known about the actual action of estrogen in the prostates of both sexes, especially when one takes into account the behavior of both the prostate during the change of hormonal balance between androgen and estrogen that occurs early of puberty and during aging of the glands. The present study aims to evaluate the morphophysiology prostate senile males and females who were exposed to synthetic estrogen levels (ethinylestradiol) in different phases: 1) during the intrauterine life, 2) early of puberty, 3) during the intrauterine life and later in early puberty. The prostates will be submitted to morphological, morphometric-stereological, immunocytochemical and ultrastructural study. So the results may help to elucidate real action of exogenous estrogen exposure in development stages and of puberty of male and female prostate and its effects during aging.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEREZ, ANA P. S.; BIANCARDI, MANOEL F.; CAIRES, CASSIA R. S.; FALLEIROS-JUNIOR, LUIZ R.; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; SANTOS, FERNANDA C. A.; TABOGA, SEBASTIAO R.. Prenatal exposure to ethinylestradiol alters the morphologic patterns and increases the predisposition for prostatic lesions in male and female gerbils during ageing. International Journal of Experimental Pathology, v. 97, n. 1, p. 5-17, . (09/16790-5, 11/06335-9)
ANTONIASSI, JULIA QUILLES; FOCHI, RICARDO ALEXANDRE; GOES, REJANE MAIRA; LEITE VILAMAIOR, PATRICIA SIMONE; TABOGA, SEBASTIAO ROBERTO. Corticosterone influences gerbil (Meriones unguiculatus) prostatic morphophysiology and alters its proliferation and apoptosis rates. International Journal of Experimental Pathology, v. 98, n. 3, p. 134-146, . (09/16790-5, 11/06335-9)
FLEURY, FERNANDA G.; GUIMARAES, LUISA R. F.; REZENDE, ELISA B.; MARTINS, TRACY M. M.; CAIRES, CASSIA R. S.; DOS SANTOS, FERNANDA C. A.; TABOGA, SEBASTIAO R.; PEREZ, ANA P. DA S.. Prenatal and pubertal exposure to 17 alpha-ethinylestradiol cause morphological changes in the prostate of old gerbils. Cell Biology International, v. 45, n. 10, . (11/06335-9, 09/16790-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PEREZ, Ana Paula da Silva. Effects of exposure to low dose of ethinylestradiol during the prenatal and puberal phases on male and female prostate of senile gerbils. 2014. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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