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Isolation and characterization of stem cells from the alveolar bone area

Grant number: 10/06936-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2010
Effective date (End): November 30, 2013
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Andrea Mantesso Pobocik
Grantee:Lucyene Miguita Luiz
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Today there is a great deal in the study of stem cells abilities to form other tissues. These features enable these cells to produce cells from different lines that actively participate in maintaining the process of homeostasis and tissue regeneration. In dentistry, Gronthos et al. 2000, found inside the dental pulp a population of stem cells that were highly proliverative, clonogenic and self-renewable and were able to regenerate tissues. Subsequent studies showed that other regions of the tooth also have stem cell populations with similar characteristics. In addition, our previous studies indicated that slow cycling cells that could migrate and have the ability to respond to injury were found more commonly in the area outside of the tooth when compared with others found inside dental pulp. These cells typically composed the second layer of cells from blood vessels walls and had close proximity with the alveolar bone. However, until now there is no study in the literature that has tried to isolate stem cells from this area even considering that the alveolar bone is commonly exposed and easily accessible during tooth extraction. Thus, the purpose of this study is to evaluate the presence of stem cells through their isolation and characterization from the alveolar bone area.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MIGUITA, LUCYENE; ZINDEL DEBONI, MARIA CRISTINA; SHARPE, PAUL; MANTESSO, ANDREA. Characterization of progenitor/stem cell population from human dental socket and their multidifferentiation potential. CELL AND TISSUE BANKING, v. 21, n. 1, . (09/00041-3, 10/06936-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LUIZ, Lucyene Miguita. Mesenchymal stem cells: Isolation and characterization of populations derived from human dental alveolus and identification and characterization of populations from mouse dental pulp. 2013. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Odontologia (FO/SDO) São Paulo.

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