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Characterization of cellular immune response, by CD4, CD8, CD4+CD25+, CD28, CD80, CD86, CD152 and NK expression, through imunohistochemistry, in canine mammary carcinoma

Grant number: 09/12698-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2010
Effective date (End): February 29, 2012
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Wilter Ricardo Russiano Vicente
Grantee:Caio de Faria Tiosso
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil


The mammary tumor study in female dogs is revealed as an excellent model for the investigation of breast tumors in humans. Malignant tumors reflect antigens that stimulate and serve as targets for tumor immunity. The innate immune system includes neutrophils, macrophages, dendritic cells and NK cells. The NK cells activity against tumor cells is correlated with reduced or no expression of MHC class I, inducing cytolysis of target cells. The acquired immune system develops participation through adaptive immunity, composed of B and T lymphocytes and co-participation of cell of innate immunity. Lymphocytes T CD4 secrete cytokines capable of activating other immune cells such as CD8 cytotoxic T cells that destroy cells infected by intracellular microorganisms. The proliferation and differentiation of T cells require signals provided by molecules of the APCs (antigen-presenting cells), called co-stimulators, B7-1 (CD80) and B7-2 (CD86), which can link to CD28, express on T helper cells, promoting T cells activation and making them to proliferate and produce cytokine, or may link to CD152, also expressed in the helper T cell, inhibiting their activation. Another form of negative regulation of the immune system are the Tregs, that inhibit activation of T cells (CD4 and CD8) and antigen-presenting cells (APCs), representing approximately 5% of CD4 T lymphocytes from peripheral blood, characterized by the expression constituent molecules FOXP3, GITR, CTLA-4 and high levels of CD25. This study aims to evaluate the expression using immunohistochemistry, lymphocyte infiltration (CD4, CD8, CD4+CD25+, CD28, CD80, CD86, CD152 and NK) in canine mammary carcinoma in order to detect the efficacy of stimulation and immune system defense in this tipe of neoplasia, that represent the majority of malignant mammary tumors diagnosed in female dogs.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAIO DE FARIA TIOSSO; FABIANA AZEVEDO VOORWALD; MAURÍCIO VELOSO BRUN; LUCIANA CRISTINA PADILHA NAKAGHI; ROBERTA MARTINS CRIVELARO; MARICY APPARICIO; WILTER RICARDO RUSSIANO VICENTE. Aplicação do portal único (SILSTM) por acesso herniário umbilical para criptorquidectomia de testículo degenerado em cão. Ciência Rural, v. 49, n. 10, . (12/25061-0, 09/12698-7)
TIOSSO, CAIO DE FARIA; VOORWALD, FAHIANA AZEVEDO; BRUN, MAURICIO VELOSO; PATINA NAKAGHI, LUCIANA CRISTINA; CRIVELARO, ROBERTA MARTINS; APPARICIO, MARICY; RUSSIANO VICENTE, WITTER RICARDO. Single incision laparoscopic surgery (SILS (TM)) using an umbilical hernial approach for cryptorchidectomy of a degenerated testis in a dog. Ciência Rural, v. 49, n. 10, . (09/12698-7, 12/25061-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TIOSSO, Caio de Faria. Caracterização da resposta imune celular pela expressão imunoistoquímica de CD4, CD8, CD28, CD152, CD56 e FOXP3 em carcinoma mamário de fêmeas caninas. 2012. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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