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Effect of Aedes aegypti saliva on the differentiation, maturation and function of dendritic cells

Grant number: 09/12247-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2010
Effective date (End): March 31, 2012
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Anderson de Sá Nunes
Grantee:Bruna Bizzarro
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:09/09892-6 - Functional immunome of Aedes aegypti saliva, AP.JP


Mosquitoes are the most important vectors of human pathogens, transmitting a wide range of emerging and re-emerging infectious diseases. In this scenario, the Aedes aegypti is a major mosquito species and transmits diseases such as yellow fever, Chikungunya fever and dengue fever, and more than half of the world population lives in risk areas. In order to successfully nourish themselves, hematophagous mosquitoes find two main challenges once they break the skin's physical integrity: a) the hemostasis and; b) the immunological system of their hosts. During the evolution process, these insects developed a salivary cocktail with an arsenal of molecules presenting several pharmacological effects. However, while the anti-hemostatic activities from saliva of hematophagous vectors are better understood, very few are known about its effects on immunity. Several works have been demonstrated that vector's saliva has an essential role in transmitting pathogens, confirming its immunomodulatory activities. Nevertheless, the mechanisms by which the saliva acts on immunity have not been totally uncovered and almost nothing is currently published in the case of Ae. aegypti. The aim of this project is to investigate the activities of Ae. aegypti saliva on the differentiation, maturation and function of dendritic cells. Considering the importance of these cells to the link of innate and acquired immune responses, the results generated by this work might contribute to the understanding of how Ae. aegypti saliva affects its host's immunity and consequently its role to disease transmission. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BIZZARRO, BRUNA; BARROS, MICHELE S.; MACIEL, CERES; GUERONI, DANIELE I.; LINO, CIRO N.; CAMPOPIANO, JULIA; KOTSYFAKIS, MICHALIS; AMARANTE-MENDES, GUSTAVO P.; CALVO, ERIC; CAPURRO, MARGARETH L.; et al. Effects of Aedes aegypti salivary components on dendritic cell and lymphocyte biology. PARASITES & VECTORS, v. 6, . (09/53637-0, 11/15569-3, 10/18216-1, 09/09892-6, 09/12247-5)
BARROS, MICHELE S.; GOMES, ELIANE; GUERONI, DANIELE I.; RAMOS, ANDERSON D.; MIROTTI, LUCIANA; FLORSHEIM, ESTHER; BIZZARRO, BRUNA; LINO, CIRO N. R.; MACIEL, CERES; LINO-DOS-SANTOS-FRANCO, ADRIANA; et al. Exposure to iBites Induces a Mixed-Type Allergic Response following Salivary Antigens Challenge in Mice. PLoS One, v. 11, n. 5, . (11/15569-3, 10/18216-1, 09/09892-6, 09/07208-0, 09/12247-5, 11/22669-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BIZZARRO, Bruna. Effect of Aedes aegypti saliva on the differentiation, maturation and function of dendritic cells and on T lymphocyte proliferation.. 2012. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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