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Effects of sexual hormones reduction due to oophorectomy and dehydroepiandrosterone (DHEA) on cardiac hypertrophy induced by the isoproterenol in young adult female rats.

Grant number: 09/11984-6
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2010
Effective date (End): August 31, 2011
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Carla Roberta de Oliveira Carvalho
Grantee:Karina Santos Teixeira
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Menopause is the permanent cessation of menstruation as a result of the low ovarian follicular function or the surgical removal of the ovaries. Cardiovascular disease is the main cause of mortality in postmenopausal women in developed countries and the difference between incidence in pre and postmenopausal women have been attributed to the action of estrogen on the cardiovascular system. Besides that, menopause is also associated with the higher corporal mass and obesity prevalence that is correlated to insulin resistance, which is associated with type II diabetes and aging. The left ventricular hypertrophy is an adaptation to hypertension. Administration of isoproterenol induces the hypertrophy of cardiomyocytes by non pressoric mechanisms that directly activate heart ²-receptors.This study aims to evaluate surgical menopause effects in female rats, by bilateral oophorectomy, on cardiac hypertrophy induced by isoproterenol treatment. More specifically, it will be appraised: (1) myocytes morphology and inflammatory infiltration of the left ventricle by coloration and (2) expression analysis of several cytokines expression - alpha-TNF, IL-1, IL-6 - and proteins involved with cell grow and apoptosis (IGF - 1R, IR, IRS-1, IRS -2, PI3K, AKT, MAPKp42/44, JAK2, SOCS).

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TEIXEIRA, Karina Santos. Effects of oophorectomy and dehydroepiandrosterone (DHEA) on the cardiac mass in rats. 2012. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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