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Synthesis and biological evaluation of phosphates, hosphoramides and carbamate derived from dihydropyranones

Grant number: 09/04627-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2009
Effective date (End): July 31, 2011
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Ronaldo Aloise Pilli
Grantee:Vanêssa Caixeta Pereira
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The syntheses of organic phosphates, phosphoramides and carbamate derived from dihydropyranones will be carried out based on the structure of goniothalamin as the lead compound. These derivatives will be evaluated against 9 human cancer cell lines and as inhibitors of phosphatases and chaperones (Hsp90).

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PEREIRA, Vanêssa Caixeta. Synthesis and biological evaluation of derivatives goniotalamina. 2011. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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