The study of complex diseases such as hypertention, diabetes and obesity is of great importance in medicine since these diseases affect many persons in our country and the world. It is believed that the pattern of variation of these diseases involves environmental and genetics components, and their possible interactions. For mapping of genes in human complex diseases, the biotechnology resources have increased very fast allowing that more dense markers maps are available. However, the development and use of analytical methodologies to analyze genetic data set have not followed on the same velocity. In this context, SNPs (Single Nucleotide Polimorphisms) platforms consisting of a million of loci represent a big analytic challenge. In this work, for mapping of genes associated with cardiovascular risk factors will be considered different mixed models formulations in the analysis of family data and SNPs platforms. To implement the proposed methodologies will be investigated computational facilities. The motivation for this project comes from the Baependi Heart Study (Fapesp Process 2007/58150-7) that aims to map genetic determinants related to cardiovascular diseases in the Brazilian population.
News published in Agência FAPESP Newsletter about the scholarship: