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Partial hepatectomy associated with the administration of nutritional hepatotrphic factors in the treatment of Wistar rats liver cirrhosis induced by tiocetamid

Grant number: 09/02904-9
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2009
Effective date (End): July 31, 2011
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:Francisco Javier Hernandez Blazquez
Grantee:Mauricio de Rosa Trotta
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Liver cirrhosis is the result of a chronic injury that causes irreversible damage of the normal hepatic architecture, resulting in functional decrease. In veterinary medicine, where liver transplantation is not yet reality, the search for new alternatives of treatment is extremely important. The partial hepatectomy stimulates liver regeneration and is able to reduce the amount of collagen in the parenchyma spread. However, this technique results in high mortality in reducing post-operative capacity of an already inadequate. The use of nutritional hepatotrophic factors was able to accelerate the regeneration of healthy liver after hepatectomy and to improve the condition of cirrhotic livers, with reduction of collagen and inhibition of pro-fibrotic genes, and improvement in liver function and morphology. Use the combination of partial hepatectomy with administration of nutritional hepatotrophic factors in livers with cirrhosis induced experimentally by tiocetamida to assess whether this treatment is able to further improve the condition of the animals submitted to him. Thus the judge after treatment volume proportion of collagen, the morpho-functional condition (histopathology and serum biochemistry), cell proliferation (immuno-histochemistry for PCNA) and the expression of genes involved in controlling the extra-cellular matrix (collagen alpha1, MMP-2, TIMP-I, and TGF-beta1)

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