Introduction: In the region of Santos and São Vicente Estuary there are many sources of pollution like capital goods industres, port terminals and open air dump sites. Heavy metals, organochlorine pesticides, polychlorinated biphenyl, dioxins and furans are stood out within toxic substances found in this region that are deleterious to health and cause mostly effects on reproductive system. This exposure is suspicious of affecting the reproduction through cellular damage or death, and can lead up to several adverse outcomes to the progeny of exposed population. Objective: Estimate and compare the prevalence of events correlated to pregnancy in exposed and non-exposed populations to environmental contaminants in the region of Santos and São Vicente Estuary. Methods: This study is part of a wide project financed by CNPq titled "Epidemiologic Study in the Baixada Santista - Santos Estuary's population: Assessment of predictors of effects and exposure to environmental contaminants" which aims to estimate the effects to health associated to environmental contaminants exposure among Baixada Santista individuals. The present study, cross sectional and exploratory, evaluate five areas of the Metropolitan Region of Baixada Santista, four areas in the towns of São Vicente, Guarujá and Cubatão (in two sites, Center and Pilões) near contaminated areas, and one area in Bertioga where there is not evidence of contamination. In each area, a sample of 820 residences was calculated based on the prevalence of congenital malformation in Brazil and the population per census district in the neighborhoods obtained by the IBGE census of 2000. A structured and previously tested questionnaire was applied in order to obtain the data. To evaluate associations between areas and pregnancy outcomes, we will use the chi-square test or Fisher's exact test, adopting a significance level of 5%. Aditionally, secundary data on pregnancy outcomes will be obtained from both the Live Births Information System and the Mortality Information System (2003-2006) through State System of Data Analysis Foundation, based on the place of residence of the mother. The outcomes will be georrefecend through thematic maps and calculated their mortality rates and prevalence of low birth weight, prematurity, congenital malformations and twinning in the regions near the contaminated areas, compared to the area without contamination.
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