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FUNCTION OF THE PROGRANULINE GROWTH FACTOR IN THE HEPATIC LINEAGE CELL DIFFERENTIATION AND PROLIFERATION DURING THE EMBRYO DEVELOPMENT OF FISHER 344 RATS

Grant number: 09/01124-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2009
Effective date (End): June 30, 2010
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Maria Angelica Miglino
Grantee:Cristiane Carlin Passos
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:08/58811-6 - The viteline enigma, AP.TEM

Abstract

Diseases involving endodermal-derivated organs affect thousands of people all over the world. The cell therapy success for treating diseases of organs originated from mesoderm and ectoderm generates excellent perspectives for its use in treating diseases of organs of endodermal origin (thyroid, lungs, liver, gallbladder and pancreas). Particularly in the liver, although regenerative proprieties are attributed in many lesions, the repairing mechanism is insufficient, making the hepatic transplant the only definitive option. Among the embryo stem cells, the fetal hepatic lineage cells may establish themselves as important sources for cell therapy in individuals with hepatic diseases, since they have high ability in hepatocytes and billiar duct cells differentiation in vitro. However, for the use of hepatic lineage embryo stem cells as a bi-potential source of differentiation, it is necessary the establishment of efficient proliferation methods in this type of cells. Evidences point to progranuline as a growth factor with high capability for the induction of cell proliferation, since it is involved in the embryo and neo-natal development. The studies regarding the fundamental mechanisms that regulate the hepatogenesis are essential for its understanding in man, since generally, they may extend to all vertebrate species. Thus, this work aims characterize the role of the new progranuline growth factor in the hepatogenesis of an animal model (rat Fisher-344) for possible use it in the processes of stem cells differentiation in vitro.Key words: progranuline, hepatogenesis, hepatic bud, cell differentiation, liver.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PASSOS, Cristiane Carlin. Function of the progranuline growth factor in the hepatic lineage cell differentiation and proliferation during the embryo development of fisher 344 rats. 2010. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.

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