Advanced search
Start date
Betweenand
Related content

BLOOD GAS ANALYSIS AND CARDIOPULMONARY PARAMETERS OF CONTINUOUS RATE INTRAVENOUS INFUSION OF LIDOCAINE IN ISOFLURANE ANESTHETIZED CALVES UNDERGOING MECHANICALLY VENTILATION

Grant number: 08/07555-0
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2009
Effective date (End): February 28, 2011
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:Paulo Sergio Patto dos Santos
Grantee:Marcelo Augusto de Araújo
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The aim of this study is to evaluate the cardiorespiratory and acid-base effects in mechanically breathing calves anesthetized by isoflurane and followed by continuous rate infusion of lidocaine. For such, eight male animals with six and eight months old, distributed in two experimental groups lidocaine group (LG) and the control group (CG) will be used. The animals will receive xylazine (0.07 mg/kg;IM) and 15 minutes later, ketamine (1.5 mg/kg; IV) associated with midazolam (0.05 mg/kg; IV). Immediately after the animals will be intubated and submitted to the isoflurane anesthesia (1.3 MAC) and subjected to mechanical ventilation. After 20 minutes, the animals of the LG will receive a bolus of 2.0 mg/kg of lidocaine followed by continuous rate infusion of 100 ¼g/kg/min. At the animals of the CG the same amount of sodium chloride 0.9% will be carried out. The observations of the variables, in both groups, will begin before (MB) and 15 minutos after (MX) xilazine administration and immediately before (M20) and 20 minutes after (M40) lidocaine or sodium chloride 0.9% administration. New mensurations will be carried out during 60 minutes (in intervals of 20 minutes) M60, M80 e M100, respectively. The recovery time will be evaluated and recorded until de animals have adopted sternal and quadrupedal position. The statistical analysis will be carried out through ANOVA following Bonferroni or t de Student test, considering the level of significance of 5% (p<0.05).

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARAUJO, MARCELO A.; DIAS, BIANCA P.; BOVINO, FERNANDA; DESCHK, MAURICIO; ABIMUSSI, CAIO J. X.; OLIVA, VALERIA N. L. S.; RODRIGUES, CELSO A.; SANTOS, PAULO S. P.. Cardiovascular effects of a continuous rate infusion of lidocaine in calves anesthetized with xylazine, midazolam, ketamine and isoflurane. VETERINARY ANAESTHESIA AND ANALGESIA, v. 41, n. 2, p. 145-152, . (09/08879-6, 08/07555-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ARAÚJO, Marcelo Augusto de. Efeitos da infusão contínua de lidocaína em bezerros anestesiados pelo isofluorano: Marcelo Augusto de Araújo. -. 2011. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.