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Lipid model membrane: methylene blue adsorption and photosensitization

Grant number: 08/07240-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2008
Effective date (End): February 28, 2013
Field of knowledge:Biological Sciences - Biophysics - Molecular Biophysics
Principal Investigator:Rosangela Itri
Grantee:Thaís Fernandes Schmidt
Host Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:05/51598-7 - Photodynamic therapy: physical, biochemical and clinical aspects, AP.TEM

Abstract

This project aims to study the photosensitization of model membranes interacting with the protein cytochrome c. The models used are unilamellar lipid vesicles (LUVs) and Langmuir monolayers. Both will be in contact with the photosensitizer methylene blue (MB) in the solution that contains the LUV or subphase in Langmuir monolayers. Further, we will study lipid membranes composed of mixtures of 1,2-diolil-sn-glycerol-3-phosphatidylcholine (DOPC) and cardiolipin (CL) at physiological pH and temperature, in order to mimic the inner membrane of mitochondria. In this context, we can contribute in the assessment of one of the possible targets of cell death by apoptosis by photosensitization of lipid membranes. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, R. M.; SIANI, P.; SCHMIDT, T. F.; ITRI, R.; DIAS, L. G.. Methylene Blue Location in (Hydroperoxized) Cardiolipin Monolayer: Implication in Membrane Photodegradation. Journal of Physical Chemistry B, v. 121, n. 36, p. 8512-8522, . (08/07240-9, 13/08166-5, 12/50680-5)
SCHMIDT, THAIS F.; CASELI, LUCIANO; OLIVEIRA, JR., OSVALDO N.; ITRI, ROSANGELA. Binding of Methylene Blue onto Langmuir Mono layers Representing Cell Membranes May Explain Its Efficiency as Photosensitizer in Photodynamic Therapy. Langmuir, v. 31, n. 14, p. 4205-4212, . (08/07240-9, 12/50680-5)

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