The apparent incompatibility between chemical and pharmacological investigation of a plant species can be solved with the strong determination of dealing rationally with the problem. The research groups on Natural Products Chemistry from the IQ-Araraquara-Unesp, on Pharmacology, from IB-Unicamp and IB-Botucatu-Unesp and on Biological Sciences, from FCF-Araraquara-Unesp have started a collaboration 4 years ago, and have already produced a significative amount of work, with relevant results on the investigation of plant species with anti-ulcer, anti-oxidant, analgesic, anti-inflammatory and antimicrobial, anti tuberculosis, immunology, cytotocity and mutagenic activities. The cytotocity and mutagenic activities are correlationation with anti-tumoral activity. These results arose from an approach that includes ethnobotanical and ethnopharmacological research, assays with crude extracts or infusions, chemical screening to determine the new chemical classes of compounds, isolation and structural determination of the compounds and use the compounds or enriched fractions to determine the possible pharmacological mechanisms of the action involved with the detected properties. This project deals with the continuation of the integrated chemical and pharmacological investigation of plant extracts, this time investigating species that composes the bioma Cerrado and Mata Atlantica of the State São Paulo, investigation ago the specie Indigofera hirsuta.To perform the phytochemical step we intend to use the usual chromatographic techniques, mainly those for the analysis of polar substances (GPC, XAD2, DCCC, HSCC, HPLC, etc), and to determine the structure of the isolated compounds through spectrometric methods (NMR, IR, UV, MS). To evaluate the anti-ulcer activities, groups the IB-Unicamp and IB-Botucatu-Unesp and on Biological Sciences, from FCF-Araraquara-Unesp.
News published in Agência FAPESP Newsletter about the scholarship: