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Biological-driven biochemical characterization of peptides and proteins isolated from Echinometra lucunter.

Grant number: 07/08478-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2008
Effective date (End): July 31, 2012
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Daniel Carvalho Pimenta
Grantee:Juliana Mozer Sciani
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


Sea urchins are marine animals present in all oceans. In Brazil, Echinometra lucunter is ubiquitous and responsible for the majority of the sea-animals accidents. These accidents are mostly traumatic, that is, the spikes penetrate the victim s skin. The animals shelter contains the pedicellaria, which are structures responsible for the nourishment and cleaning of the animal. In some sea urchin species, like E lucunter, there may be venom glands associated to the pedicellaria; however, these toxins are not known for they are not relevant to the human accidents. A few peptides have already been isolated from other sea urchin species pedicellaria and some bradykinin-like and histamine-like activities have been reported. This work aim is to obtain the toxin from E lucunter collected at the shores of São Paulo, isolate and biochemically characterize peptides and proteins present in this toxins and test for pharmacological activities. In this way, it is our understanding that this project would collaborate to a better comprehension of the toxins present in the sea urchin pedicellaria. Moreover, new biologically active relevant molecules can be described presenting not only bioactivity but also biotechnological interest.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SCIANI, JULIANA MOZER; MARQUES-PORTO, RAFAEL; LOURENCO JUNIOR, AIRTON; ORSI, RICARDO DE OLIVEIRA; FERREIRA JUNIOR, RUI SEABRA; BARRAVIERA, BENEDITO; PIMENTA, DANIEL CARVALHO. Identification of a novel melittin isoform from Africanized Apis mellifera venom. Peptides, v. 31, n. 8, p. 1473-1479, . (07/05159-7, 07/02476-1, 07/08478-6)
SCIANI, JULIANA MOZER; ANGELI, CLAUDIA BLANES; ANTONIAZZI, MARTA M.; JARED, CARLOS; PIMENTA, DANIEL CARVALHO. Differences and Similarities among Parotoid Macrogland Secretions in South American Toads: A Preliminary Biochemical Delineation. SCIENTIFIC WORLD JOURNAL, . (07/08478-6, 07/02476-1)
SCIANI, JULIANA MOZER; ZYCHAR, BIANCA CESTARI; GONCALVES, LUIS ROBERTO CAMARGO; NOGUEIRA, THIAGO DE OLIVEIRA; GIORGI, RENATA; PIMENTA, DANIEL CARVALHO. Pro-inflammatory effects of the aqueous extract of Echinometra lucunter sea urchin spines. Experimental Biology and Medicine, v. 236, n. 3, p. 277-280, . (07/08478-6, 07/02476-1)
FERREIRA JUNIOR, RUI S.; SCIANI, JULIANA M.; MARQUES-PORTO, RAFAEL; LOURENCO JUNIOR, AIRTON; ORSI, RICARDO DE O.; BARRAVIERA, BENEDITO; PIMENTA, DANIEL C.. Africanized honey bee (Apis mellifera) venom profiling: Seasonal variation of melittin and phospholipase A(2) levels. Toxicon, v. 56, n. 3, p. 355-362, . (07/05159-7, 07/02476-1, 07/08478-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SCIANI, Juliana Mozer. Toxinologic studies about Echinometra lucunter sea urchin.. 2012. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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