Advanced search
Start date

Structural and functional characterization of vesicular structures exported by the pathogenic fungus Paracoccidioides brasiliensis

Grant number: 07/04757-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2007
Effective date (End): November 30, 2011
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Rosana Puccia
Grantee:Milene Carmes Vallejo
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:06/05095-6 - Analysis of exported vesicular structures and of secreted molecules by the pathogenic fungi Paracoccidioides brasiliensis e Cryptococcus neoformans, AP.TEM


We are using the pathogen Paracoccidioides brasiliensis as a fungal model to study extracellular membranous vesicles (exosome-like). We intend to isolate and characterize the vesicles, determine their composition in comparison with cell wall proteins, verify their immunomodulatory role, and the role of monohexosylceramide in their secretion mechanism. The importance of exocytic vesicles as a secretion mechanism, transport of immunomodulatory molecules and their relevance in host/parasite relationship has been recently recognized among microorganisms, including the oportunistic fungus Cryptococcos neoformans. Two abstract meetings record preliminary findings by our group in P. brasiliensis and by others in Histoplasma capsulatum. In this project, we will compare the analyses in two genetically distinct isolates that evoke different profiles of infection in mice. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VALLEJO, MILENE C.; NAKAYASU, ERNESTO S.; LONGO, LARISSA V. G.; GANIKO, LUCIANE; LOPES, FELIPE G.; MATSUO, ALISSON L.; ALMEIDA, IGOR C.; PUCCIA, ROSANA. Lipidomic Analysis of Extracellular Vesicles from the Pathogenic Phase of Paracoccidioides brasiliensis. PLoS One, v. 7, n. 6, p. e39463, . (07/04757-8, 06/05095-6)

Please report errors in scientific publications list by writing to: