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Epithelial stem cells from oral mucosa: isolation, characterization and response to injury

Grant number: 10/06574-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2010
Effective date (End): March 31, 2013
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Andrea Mantesso Pobocik
Grantee:Felipe Perozzo Daltoe
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The oral mucosa has increasingly calling attention of the literature as a source of cells for tissue engineering and regenerative medicine. It is recognized that the epithelial tissue is maintained by a progeny of particular cells, called stem cells, which are self maintained and characteristically present higher proliferative potential and capacity to differentiate into other types that constitute the tissue. Until now, it is known that the epithelial stem cells are rare and located in specific niches, but their isolation remains a challenge. Herein we propose to identify and isolate a population of progenitors/stem cells from oral keratinocytes cultures. Once isolated, we will characterize the different clones by proliferation assays; surface cell markers and their capacity to differentiate and reconstruct the layers of the epithelium and respond to injury. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
DALTOE, Felipe Perozzo. Isolation, characterization and response to damage of humam epithelial stem cells from human oral mucosa. 2013. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Odontologia (FO/SDO) São Paulo.

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