The increased incidence of metabolic disorders related to lipid metabolism such as obesity, atherosclerosis, metabolic syndrome and other dyslipidemias are related to changes in dietary habits during the last decades, in which there is an increase in fat intake. Studies have shown that a high-fat diet can cause changes in various organs such as liver, kidneys and intestine, because they are directly linked to lipid metabolism, and they express receptors responsible for uptake and transport of these. During pregnancy and lactation the diet consumed by the mother can influence on offspring, leading him to a predisposition to a variety of disorders. The ABCA1 protein is directly responsible for the efflux of cellular cholesterol and phospholipids to apolipoprotein AI (ApoA-I), the absence or reduction of the function can cause serious complications, because the Apo-I-free lipids is rapidly removed by the kidneys avoiding the formation of HDL. SR-BI is a membrane receptor that can also mediate the selective uptake of cholesteryl esters from HDL and LDL to the cells, ant it promotes the efflux of free cholesterol to lipoproteins. Thus, these cholesterol transporters proteins are considered a potent anti-atherogenic. Given the information presented, the aim of this study is to verify the effects of a maternal high-fat diet on cholesterol transport proteins SR-BI and ABCA1 in the small intestine, liver and kidney of the offspring at different stages of postnatal development.
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