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Simultaneous analysis of multi-residue antibiotics in water and sediments by headspace bar sorptive extraction with in situ derivatization coupled to GC / MS

Grant number: 07/03844-4
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): January 01, 2008
Effective date (End): August 31, 2012
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Fernando Mauro Lanças
Grantee:Paulo Clairmont Feitosa de Lima Gomes
Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil


Pharmaceutical residues in waste, surface, and drinking water, called micropollutants, have been recognized to cause damage to human and aquatic system. The most significant pathway of pharmaceuticals into the aquatic environment is through wastewater systems following consumption and excretion by humans, and via effluents from landfills, farms and abattoirs. Conventional wastewater treatment plants (WWTPs) can eliminate some antibiotics while others may be hard to be removed in the process, and can therefore reach the aquatic environment. In recent years, an increasing knowledge of potentially dangerous consequences of the human exposure to pharmaceuticals from the environment has been described. Exposure to antibiotic residues in aquatic system is a particular concern because of the trace level concentration range, which can result in the development of antibiotic-resistant bacteria. Consequently, it is essential the development of reliable analytical methods, which enable rapid, sensitive and selective determination of pharmaceuticals in environment at trace level concentration ranges. Modern extraction methods like Stir Bar Sorptive Extraction (SBSE) has proved to be an excellent methodology for sampling and analysis in environmental matrices. It is a simple, fast, and solventless extraction technique. It also allows a high number of extractions with the same stir bar, reducing its cost. The present work aims the development of a sensitive, selective and environmental friendly multi-residual analytical methodology based on headspace sorptive bar extraction with in situ derivatization followed by gas chromatography mass-spectrometry (GC-MS). (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOMINGUES NAZARIO, CARLOS EDUARDO; DE LIMA GOMES, PAULO CLAIRMONT FEITOSA; MAURO LANCAS, FERNANDO. Analysis of fluoxetine and norfluoxetine in human plasma by HPLC-UV using a high purity C18 silica-based SPE sorbent. ANALYTICAL METHODS, v. 6, n. 12, p. 4181-4187, . (05/59360-0, 07/03844-4)
BARREIRO, JULIANA CRISTINA; LUIZ, ANDERSON LUIGI; FERNANDES MACIEL, SUELLEN CRISTIANE; SOARES MACIEL, EDVALDO VASCONCELOS; LANCAS, FERNANDO MAURO. Recent approaches for on-line analysis of residues and contaminants in food matrices: A review. JOURNAL OF SEPARATION SCIENCE, v. 38, n. 10, p. 1721-1732, . (05/59360-0, 07/03844-4)
LIMA GOMES, PAULO C. F.; BARNES, BRIAN B.; SANTOS-NETO, ALVARO J.; LANCAS, FERNANDO M.; SNOW, NICHOLAS H.. Determination of steroids, caffeine and methylparaben in water using solid phase microextraction-comprehensive two dimensional gas chromatography-time of flight mass spectrometry. Journal of Chromatography A, v. 1299, p. 126-130, . (05/59360-0, 07/03844-4)
BARLETTA, JULIANA Y.; DE LIMA GOMES, PAULO C. F.; DOS SANTOS-NETO, ALVARO J.; LANCAS, FERNANDO M.. Development of a new stir bar sorptive extraction coating and its application for the determination of six pesticides in sugarcane juice. JOURNAL OF SEPARATION SCIENCE, v. 34, n. 11, p. 1317-1325, . (05/59360-0, 07/03844-4)
FEITOSA DE LIMA GOMES, PAULO CLAIRMONT; BARLETTA, JULIANA YAMASHITA; DOMINGUES NAZARIO, CARLOS EDUARDO; SANTOS-NETO, ALVARO JOSE; VON WOLFF, MARYA ANNE; REGANHAN CONEGLIAN, CASSIANA MARIA; UMBUZEIRO, GISELA ARAGAO; LANCAS, FERNANDO MAURO. Optimization of in situ derivatization SPME by experimental design for GC-MS multi-residue analysis of pharmaceutical drugs in wastewater. JOURNAL OF SEPARATION SCIENCE, v. 34, n. 4, p. 436-445, . (05/59360-0, 07/03844-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GOMES, Paulo Clairmont Feitosa de Lima. Development and application of microextraction sample preparation techniques to determine pharmaceutical drugs in the environment. 2012. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC/BT) São Carlos.

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