The project seeks to investigate the interactions of articaine, a potent local anesthetics widely used in medical and dental surgery applications, with a biomembrane model consinsting of a POPC bilayer, using Molecular Dynamics computer simulations under biologically relevant thermodymamic conditions. We intend to investigate the tranversal distribution of the drug wihin the bilayer, and specific drug-lipid interactions. In addition, we propose to examine the effects of articaine upon the bilayer ordering and dynamics. Studies should be caried out for both neutral and protonated states of the drug in order to provide valuable information about the behavior of these systems at a molecular level.
News published in Agência FAPESP Newsletter about the scholarship: