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Interactions of local anesthetics with phospholipid bilayers

Grant number: 07/02629-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2007
Effective date (End): July 31, 2009
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Munir Salomao Skaf
Grantee:Érica Teixeira Prates
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The project seeks to investigate the interactions of articaine, a potent local anesthetics widely used in medical and dental surgery applications, with a biomembrane model consinsting of a POPC bilayer, using Molecular Dynamics computer simulations under biologically relevant thermodymamic conditions. We intend to investigate the tranversal distribution of the drug wihin the bilayer, and specific drug-lipid interactions. In addition, we propose to examine the effects of articaine upon the bilayer ordering and dynamics. Studies should be caried out for both neutral and protonated states of the drug in order to provide valuable information about the behavior of these systems at a molecular level.

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PRATES, ERICA TEIXEIRA; RODRIGUES DA SILVA, GUSTAVO HENRIQUE; SOUZA, THAIS F.; SKAF, MUNIR S.; PICKHOLZ, MONICA; DE PAULA, ENEIDA. Articaine interaction with phospholipid bilayers. Journal of Molecular Structure, v. 1222, . (14/14457-5, 17/15174-5, 07/02629-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PRATES, Érica Teixeira. Molecular dynamics of articaine in POPC membranes. 2009. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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