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Evaluation of medetomidine cardiovascular effects in horses pretreated with hyoscine

Grant number: 06/05274-8
Support type:Scholarships in Brazil - Master
Effective date (Start): June 01, 2007
Effective date (End): May 31, 2009
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal researcher:Carlos Augusto Araújo Valadão
Grantee:João Henrique Perotta
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil


The medetomidine is a alpha-2 agonist drug that produces sedation and analgesia accompanied of bradycardia, hypotension and, sometimes, second-degree atrioventricular block. Antimuscarinic drugs have been recommended to minimize the cardiovascular effects of alpha-2 agonists, which the hyoscine-N-butyl bromide has least effect of equine gastrointestinal tract. In this way, the purpose of this study is to investigate the cardiovascular effects of medetomidine in horses pretreated with hyoscine-N-butyl bromide administered intravenously or intramuscularly.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEROTTA, JOAO H.; CANOLA, PAULO A.; LOPES, MARISTELA C. S.; EVORA, PATRICIA M.; MARTINEZ, PAULO E. B.; ESCOBAR, ANDRE; VALADAO, CARLOS A. A.. Hyoscine-N-butylbromide premedication on cardiovascular variables of horses sedated with medetomidine. VETERINARY ANAESTHESIA AND ANALGESIA, v. 41, n. 4, p. 357-364, . (06/05274-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PEROTTA, João Henrique. Efeitos clínicos e comportamentais da injeção de medetomidina em equinos pré-medicados com hioscina. 2009. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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