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Liquid crystal nanodispersions as delivery systems for photosensitizers in the photodynamic therapy of skin cancer: in vitro and in vivo cutaneous permeation and retention tests

Grant number: 06/03929-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): February 01, 2007
Effective date (End): January 31, 2010
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Maria Vitória Lopes Badra Bentley
Grantee:Fábia Cristina Rossetti
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Photodynamic therapy (PDT) has been designated as a "'promising new modality in the treatment of cancer" since the early 1980s. This can be partly attributed to the very attractive basic concept of PDT; the combination of two therapeutic agents, a photosensitizing drug and light, which are relatively harmless by themselves but combined (in the presence of oxygen) ultimately cause more or less selective tumour destruction (BROW; BROW; WALKER, 2004; ZEITOUNI; OSEROFF; SHIEH, 2003). The photosensitizers (PS) used in the PDT aimed to treat skin cancer have an inadequate hydrophilic/lipophilic balance, that difficult their penetration through the stratum corneum where the cancerous cells are located (FABRIS et. al., 2006).Recently, the development of delivery systems and promotion enhancers to optimize the cutaneus delivery of PS are a promising and unexplored research field for PDT of skin cancer (DE ROSA; BENTLEY, 2000; LOPEZ et al., 2004).Delivery systems composed by monoolein, a biocompatible polar lipid, and water are able to increase the skin permeation of drugs and controlled their delivery (DE ROSA et. al., 2003).The project propose to develop topical delivery systems based on liquid-crystalline dispersions of monoolein to deliver the PS zinc phthalocyanine and protoporphyrin IX in the PDT and to evaluate their in vitro and in vivo permeation and retention studies.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROSSETTI, FABIA CRISTINA; DEPIERI, LIVIA VIEIRA; PRACA, FABIOLA GARCIA; DEL CIAMPO, JOSE ORESTES; FANTINI, MARCIA C. A.; RIEMMA PIERRE, MARIA BERNADETE; TEDESCO, ANTONIO CLAUDIO; LOPES BADRA BENTLEY, MARIA VITORIA. Optimization of protoporphyrin IX skin delivery for topical photodynamic therapy: Nanodispersions of liquid-crystalline phase as nanocarriers. European Journal of Pharmaceutical Sciences, v. 83, p. 99-108, . (06/03929-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ROSSETTI, Fábia Cristina. Liquid Crystal nanodispersions as delivery systems for photosensitizers in the photodynamic therapy of skin cancer: in vitro and in vivo cutaneous permeation and retention tests.. 2010. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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