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Development of immunoassay techniques for microcystin and anatoxin-a detection in environmental samples

Grant number: 05/03505-0
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): June 01, 2006
Effective date (End): December 31, 2009
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Ernani Pinto Junior
Grantee:Fabyana Maria dos Anjos
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Microcystins are cyclic heptapeptides that show hepatotoxic activity. Previous experiments have demonstrated the viability to produce immunoassays to detect these toxins in environmental samples. However, most of these immunoassays utilize polyclonal antibodies and, for this reason, are not very effective since cross reaction and false positive results can happen. It is known that samples collected at Billings and Guarapiranga Reservoirs (São Paulo city) presented microcystin variants such as [Asp3]-MC-LR, MC-LR, MC-RR e MC-YR.Our aim is to develop an immunoassay kit with monoclonal antibodies in order to detect MC-LR and other microcystin variants. Prof. Dr. Adelaide Vaz (FCF-FBC/USP) fully cooperates with this project. This project is supported by FAPESP (03/06443-0). (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ANJOS, Fabyana Maria dos. Development of immunoassay techniques to detect microcystin in environmental samples. 2009. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.

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