| Grant number: | 05/03255-3 |
| Support Opportunities: | Scholarships in Brazil - Master |
| Effective date (Start): | March 01, 2006 |
| Effective date (End): | January 31, 2008 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Organic Chemistry |
| Principal Investigator: | Ronaldo Aloise Pilli |
| Grantee: | Cilene Marquissolo |
| Host Institution: | Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract The total synthesis of (S)-3-carbomethoxy goniothalamin (5) will be carried out from the catalytic asymmetric allylation of trans-cinnamaldehyde, followed by ring-closing metathesis reaction. For the preparartion of (S,S)-bis-dihydropyranone (21)a bidirectional approach will be employed involving the bis catalytic asymmetric allylation of trnas-1,4-butenedial. These compounds which are expected to act as more efficient Michael acceptors will be evaluated as cytotoxic agents against 8 human cancer cell lines. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
| More itemsLess items | |
| TITULO | |
| Articles published in other media outlets ( ): | |
| More itemsLess items | |
| VEICULO: TITULO (DATA) | |
| VEICULO: TITULO (DATA) | |