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Synthesis and evaluation of goniothalamin analogues cytotoxicity

Grant number: 05/03255-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2006
Effective date (End): January 31, 2008
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Ronaldo Aloise Pilli
Grantee:Cilene Marquissolo
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The total synthesis of (S)-3-carbomethoxy goniothalamin (5) will be carried out from the catalytic asymmetric allylation of trans-cinnamaldehyde, followed by ring-closing metathesis reaction. For the preparartion of (S,S)-bis-dihydropyranone (21)a bidirectional approach will be employed involving the bis catalytic asymmetric allylation of trnas-1,4-butenedial. These compounds which are expected to act as more efficient Michael acceptors will be evaluated as cytotoxic agents against 8 human cancer cell lines.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARQUISSOLO, Cilene. Synthesis and biological activity of furan analogues of goniothalamin. 2009. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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