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Chemical characterization by chromatography and spectroscopy methods for quality control of raw materials and pharmaceutical forms of "quebra-pedra"

Grant number: 05/01721-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2006
Effective date (End): December 31, 2008
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Quezia Bezerra Cass
Grantee:Lucia Regina Rocha Martins
Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil


The use of plants by brazilian population stimulated, in the last decades, the process of industrialization and trading of many products of vegetal source. Parallel to industrial increase, it was created rules by ANVISA, that aim to standardize the quality and to warrant the efficiency and safety of this medicines for the people. However the sanitary legislation is severe, the industrial setor of national herbal medicines still don’t dispose of accurate and reproducible methodologies that allow the analysis of herbals samples of unequivocal and sufficient manner. The utilization of the High Performance Liquid Chromatograph (HPLC), conjugate with spectroscopic analysis technic of diode array (DAD) and mass spectrometry (MS) consist in useful tools for the production of completes chemicals patterns, reproducible and suitable for analysis of herbals samples. Through quimiometric analysis of spectroscopics data of Nuclear Magnetic Ressonance (NMR), attained by references samples, to be able to settle patterns of similarity and phytoequivalence of the available commercial products. In this study, the cited tools will are utilize in standard herbals samples, in herbals raw materials and in commercials medicines of the “quebra-pedra”, name popular impute to vegetal species of the genus Phyllantus.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROCHA MARTINS, LUCIA REGINA; PEREIRA-FILHO, EDENIR RODRIGUES; CASS, QUEZIA BEZERRA. Chromatographic profiles of Phyllanthus aqueous extracts samples: a proposition of classification using chemometric models. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 400, n. 2, p. 469-481, . (05/01721-7)

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