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Understanding the evolution of fungicide resistance in field populations of the wheat blast pathogen from Brazil: can we learn lessons for future disease management?

Grant number: 17/50456-1
Support type:Regular Research Grants
Duration: April 01, 2018 - March 31, 2019
Field of knowledge:Agronomical Sciences - Agronomy - Plant Health
Cooperation agreement: BBSRC, UKRI ; Newton Fund, with FAPESP as a partner institution in Brazil
Principal researcher:Paulo Cezar Ceresini
Grantee:Paulo Cezar Ceresini
Principal researcher abroad: Bart Fraaije
Institution abroad: Rothamsted Research, England
Home Institution: Faculdade de Engenharia (FEIS). Universidade Estadual Paulista (UNESP). Campus de Ilha Solteira. Ilha Solteira , SP, Brazil


Some plant diseases are becoming very difficult to control due to lack of host resistance cultivars and limited availability of fungicide products for crop protection. Fungicide resistance, tighter regulations and a slowing pipeline of new products are reducing the range of available chemical classes. This leads to greater dependence on fewer active ingredients with fungicide modes of action, subsequently, increases the selective pressure for further cases of resistance. In order to increase the shelf life of new and currently available fungicide actives, "evolution-smart" (i.e., guided) integrated pest management strategies are needed. This project will focus on the plant pathogen Pyricularia graminis-tritici (Pygt), the causal agent of wheat blast, an important fungal disease in Brazil that is very difficult to control, with several groups of fungicides (e.g. sterol demethylase, quinone outside and succinate dehydrogenase inhibitors) became (or having become) ineffective. To improve wheat blast control, a better understanding of the disease epidemiology, the fungicide sensitivity/resistance status and new disease management strategies are needed. In this project we will focus on ali three aspects using the lastest spore trapping technology, fungicide pheno- anel genotyping sensitivity/resistance assays as well as a fungicide target protein expression system, enabling to investigate the impact of target mutations on enzyme function and fungicide binding. These tools are generic and can be applied for other plant pathogens. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DORIGAN, ADRIANO FRANCIS; DE CARVALHO, GISELLE; POLONI, NADIA MARIA; NEGRISOLI, MATHEUS MEREB; NUNES MACIEL, JOAO LEODATO; CERESINI, PAULO CEZAR. Resistance to triazole fungicides in Pyricularia species is associated with invasive plants from wheat fields in Brazil. Acta Scientiarum. Agronomy, v. 41, . (17/50456-1, 15/10453-8, 13/10655-4)
VICENTINI, SAMARA N. C.; CASADO, PRISCILA S.; DE CARVALHO, GISELLE; MOREIRA, I, SILVINO; DORIGAN, ADRIANO F.; SILVA, TATIANE C.; SILVA, ABIMAEL G.; CUSTODIO, ADRIANO A. P.; GOMES, ANA CAROLINA S.; MACIEL, JOAO L. NUNES; et al. onitoring of Brazilian wheat blast field populations reveals resistance to QoI, DMI, and SDHI fungicide. PLANT PATHOLOGY, v. 71, n. 2, . (17/50456-1, 19/12509-1, 15/10453-8, 18/21197-0, 13/10655-4, 20/07611-9)
CERESINI, PAULO CEZAR; CASTROAGUDIN, VANINA LILIAN; RODRIGUES, FABRICIO AVILA; RIOS, JONAS ALBERTO; AUCIQUE-PEREZ, CARLOS EDUARDO; MOREIRA, SILVINO INTRA; CROLL, DANIEL; ALVES, EDUARDO; DE CARVALHO, GISELLE; NUNES MACIEL, JOAO LEODATO; et al. Wheat blast: from its origins in South America to its emergence as a global threat. MOLECULAR PLANT PATHOLOGY, v. 20, n. 2, p. 155-172, . (13/10655-4, 15/10453-8, 14/25904-2, 17/50456-1)
POLONI, NADIA MARIA; CARVALHO, GISELLE; NUNES CAMPOS VICENTINI, SAMARA; FRANCIS DORIGAN, ADRIANO; NUNES MACIEL, JOAO LEODATO; MCDONALD, BRUCE A.; INTRA MOREIRA, SILVINO; HAWKINS, NICHOLA; FRAAIJE, BART A.; KELLY, DIANE E.; et al. Widespread distribution of resistance to triazole fungicides in Brazilian populations of the wheat blast pathogen. PLANT PATHOLOGY, v. 70, n. 2, . (13/10655-4, 19/12509-1, 17/50456-1, 18/21197-0, 15/10453-8)

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