Advanced search
Start date

Magnetic nanoparticles for biomolecules immobilization

Grant number: 17/00850-5
Support Opportunities:Research Grants - Innovative Research in Small Business - PIPE
Duration: April 01, 2018 - December 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:William Alberto Leonel Ferreira
Grantee:William Alberto Leonel Ferreira
Host Company:Nchemi Engenharia de Materiais Ltda
CNAE: Fabricação de aditivos de uso industrial
Fabricação de produtos químicos não especificados anteriormente
City: São Carlos
Associated grant(s):18/22473-1 - Magnetic nanoparticles for biomolecules immobilization, AP.PIPE
Associated scholarship(s):18/07352-3 - Magnetic nanoparticles for biomolecules immobilization, BP.PIPE


The biomedical field demands quick and simple diagnosis along with effective and non-invasive methods. Development of building blocks with specific functions can be the answer to this demand; magnetic nanoparticles (MNPs) have became a promising technology because of its low toxicity and unique magnetic properties. A peculiar class of nanomaterials that can demonstrate an outstanding performance are the so called functionalized nanoparticles. These are particles that present organic molecules bonded onto its surface, i.e., an organic layer. Hence, the MNPs have provided the optimization of regular techniques or the development of totally new ones, such as bioconjugation, magnetic hyperthermia, magnetic resonance imaging and target drug delivery. For these applications, the MNPs requirements include controlled size, high dispersivity and compatibility in biological environment. In this context, this project focus on the development of a method to insert ligands with functional groups responsible for further coupling with biomolecules in the MNPs. The nanoparticles synthesis were developed by the nChemi company. The methodology which perform the best cost/benefit ratio will be further improved. Moreover, the characterization techniques that will be used to analyze the sample quality and characteristics are: XRD, TEM, FT-IR and TGA. The immobilization efficiency will be observed with an LC-MS, in an enzymatic kinetics assay using the enzyme acetylcholinesterase from Electrophorus electricus as standard. The nChemi enterprise group, the Functional Materials Center (CEPID 2013/07296-2) and the chromatography research nucleus (SEPARARE) technically support this project as well. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: