Advanced search
Start date

Impact of physical training on resistance to insulin action, lipid content, angiogenesis and fibrogenesis of skeletal muscle in patients with idiopathic inflammatory myopathies

Grant number: 17/13109-1
Support Opportunities:Regular Research Grants
Duration: March 01, 2018 - February 29, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Samuel Katsuyuki Shinjo
Grantee:Samuel Katsuyuki Shinjo
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Bruno Gualano ; Sueli Mieko Oba Shinjo ; Suely Kazue Nagahashi Marie ; Walcy Paganelli Rosolia Teodoro


Idiopathic inflammatory myopathies (MII) are rare systemic autoimmune diseases associated with high morbidity and functional disability. They can be classified as dermatomyositis (DM), polymyositis (PM), immune-mediated necrotizing myopathy (IMNM), inclusion body myositis (IBM), among others. Patients have primarilt skeletal muscle involvement, accompanied by decreased muscle strength, muscle function, quality of life and aerobic capacity. In addition, they present muscle atrophy/hypotrophy, associated with increased fibrogenesis and lipogenesis, and decreased angiogenesis and oxidative capacity of lipids in muscle tissues. Moreover, our group showed for the first time in the literature that patients with MII have a high prevalence of metabolic syndrome and a peripheral increase of insulin resistance (IR). Increased IR in skeletal muscle further impairs oxidation of lipids in this territory, culminating in the accumulation of this metabolite. In this context, physical training could improve and favor oxidative capacity and angiogenesis. On the other hand, it could attenuate IR, as well as the mechanism of lipogenesis and fibrogenesis in muscle tissues. Clinically, there would be improvement of aerobic capacity, muscle strength and function, quality of life, and decrease of morbimortality. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, ALEXANDRE MOURA; MISSE, RAFAEL GIOVANI; PIRES BORGES, ISABELA BRUNA; SHINJO, SAMUEL KATSUYUKI. The aerobic capacity in patients with antisynthetase syndrome and dermatomyositis. ADVANCES IN RHEUMATOLOGY, v. 60, n. 1, . (17/13109-1, 16/23574-0, 18/08735-3, 16/20371-1)
DE OLIVEIRA, DIEGO SALES; DE SOUZA, JEAN MARCOS; SHINJO, SAMUEL KATSUYUKI. Beyond medicine: Physical exercise should be always considered in patients with systemic autoimmune myopathies. AUTOIMMUNITY REVIEWS, v. 18, n. 3, p. 315-316, . (16/19771-5, 17/13109-1)
DE SOUZA, J. M.; DE OLIVEIRA, D. S.; PERIN, L. A.; MISSE, R. G.; DOS SANTOS, A. M.; GUALANO, B.; DE SA PINTO, A. L.; ROSCHEL, H.; LIMA, F. R.; SHINJO, S. K.. Feasibility, safety and efficacy of exercise training in immune-mediated necrotising myopathies: a quasi-experimental prospective study. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 37, n. 2, p. 235-241, . (17/13109-1, 16/23574-0, 17/06794-0, 16/19771-5)
DE OLIVEIRA, DIEGO SALES; PIRES BORGES, ISABELA BRUNA; DE SOUZA, JEAN MARCOS; GUALANO, BRUNO; RODRIGUES PEREIRA, ROSA MARIA; SHINJO, SAMUEL KATSUYUKI. Exercise training attenuates insulin resistance and improves beta-cell function in patients with systemic autoimmune myopathies: a pilot study. CLINICAL RHEUMATOLOGY, v. 38, n. 12, p. 3435-3442, . (16/19771-5, 16/20371-1, 17/13109-1)
DE SOUZA, JEAN MARCOS; HOFF, LEONARDO SANTOS; SHINJO, SAMUEL KATSUYUKI. Intravenous human immunoglobulin and/or methylprednisolone pulse therapies as a possible treat-to-target strategy in immune-mediated necrotizing myopathies. RHEUMATOLOGY INTERNATIONAL, v. 39, n. 7, p. 1201-1212, . (17/13109-1)
PIRES BORGES, ISABELA BRUNA; DE OLIVEIRA, DIEGO SALES; MISSE, RAFAEL GIOVANI; DOS SANTOS, ALEXANDRE MOURA; COSTA HONG, VALERIA APARECIDA; BORTOLOTTO, LUIZ APARECIDO; SHINJO, SAMUEL KATSUYUKI. Safety of Atorvastatin in Patients With Stable Systemic Autoimmune Myopathies A Pilot Longitudinal Study. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 27, n. 6, p. S236-S241, . (16/19771-5, 16/23574-0, 18/08735-3, 17/13109-1, 16/20371-1)
MISSE, RAFAEL GIOVANI; PIRES BORGES, ISABELA BRUNA; SHINJO, SAMUEL KATSUYUKI. Endothelial function features and properties of large vessel behavior in systemic autoimmune diseases: a cross-talk among cardiovascular disease risk factors. AUTOIMMUNITY REVIEWS, v. 18, n. 6, p. 637-638, . (17/13109-1, 16/23574-0, 16/20371-1)
PIRES BORGES, ISABELA BRUNA; DE OLIVEIRA, DIEGO SALES; NAGAHASHI MARIE, SUELY KAZUE; LENARIO, ANTONIO MARCONDES; OBA-SHINJO, SUELI MIEKO; SHINJO, SAMUEL KATSUYUKI. Exercise Training Attenuates Ubiquitin-Proteasome Pathway and Increases the Genes Related to Autophagy on the Skeletal Muscle of Patients With Inflammatory Myopathies. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 27, n. 6, p. S224-S231, . (16/19771-5, 19/11367-9, 17/13109-1)
DE OLIVEIRA, DIEGO SALES; MISSE, RAFAEL GIOVANI; LIMA, FERNANDA RODRIGUES; SHINJO, SAMUEL KATSUYUKI. Physical exercise among patients with systemic autoimmune myopathies. ADVANCES IN RHEUMATOLOGY, v. 58, . (17/13109-1)

Please report errors in scientific publications list by writing to: