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Mechanical and microbiological characterization of the novel bioactive composites

Grant number: 17/50290-6
Support Opportunities:Regular Research Grants
Duration: February 01, 2018 - January 31, 2020
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Convênio/Acordo: University of New South Wales
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Flavia Gonçalves
Grantee:Flavia Gonçalves
Principal researcher abroad: Lamie Kruzic
Institution abroad: University of Wales, Wales
Host Institution: Universidade Ibirapuera (UNIB). Campus Chácara Flora. São Paulo , SP, Brazil

Abstract

Recurrent caries are one of the main reasons for resin composite restorations failures. There is currently a need to develop improved and longer lasting dental restorative materials with the ability to self-heal while resisting recurrent caries via an antimicrobial effect. The current FAPESP regular grant, aims to develop a bioactive restorative composite with antimicrobial and remineralizing properties using chitosan nanospheres loaded with calcium phosphate. However, more studies are needed to improve our understanding of the mechanical properties, microstructure and mechano-biological performance of these novel restorative materials. Accordingly, the UNSW team aims to use their novel methodologies to evaluate the in vitro composite mechanical performance. Their unique methodology enables mechanical testing in a simulated oral-like environment, which includes the microbiological, physical, and chemical factors experienced in the oral environment. Moreover, the proposed collaboration with the FAPESP project will provide the UNSW team unique access to knowledge regarding chitosan nanosphere applications for dental materials. The nanotechnology, which can delivery not only calcium phosphate but several drugs and growth factors of interest, also has the potential to be transferred to different matrix materials, such as resin-modified glass ionomer (RMGIC), an area of current research interest to the UNSW team. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KRUZIC, JAMIE J.; ARSECULARATNE, JOSEPH A.; TANAKA, CARINA B.; HOFFMAN, MARK J.; CESAR, PAULO F.. Recent advances in understanding the fatigue and wear behavior of dental composites and ceramics. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 88, p. 504-533, . (17/11913-8, 17/50290-6)
LOPES, DIANA PEREIRA; FREITAS, SELMA REGINA MUNIZ; TANAKA, CARINA BAPTISTON; DELECHIAVE, GIOVANNE; KIKUCHI, LUCIA NOBUCO TAKAMORI; BRAGA, ROBERTO R.; KRUZIC, JAMIE J.; MOREIRA, MARIA STELLA; BOARO, LETICIA CRISTINA CIDREIRA; CATALANI, LUIZ HENRIQUE; et al. Synthesis of Submicrometric Chitosan Particles Loaded with Calcium Phosphate for Biomedical Applications. AAPS PHARMSCITECH, v. 24, n. 2, p. 9-pg., . (16/13114-2, 17/50290-6)

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Filed patent(s) as a result of this research project

PARTÍCULAS DE QUITOSANA CARREGADAS COM FOSFATO DE CÁLCIO E COMPÓSITO RESINOSO CONTENDO TAIS PARTÍCULAS BR102019015388-1 - Universidade de São Paulo (USP) . ROBERTO RUGGIERO BRAGA / Luiz Henrique Catalani / CARINA BAPTISTON TANAKA / DIANA PEREIRA LOPES / FLÁVIA GONÇALVES / JAMIE JOSEPH KRUZIC / MARIA STELLA NUNES ARAÚJO MOREIRA - July 2019, 25